NCT04830423 is a NA clinical trial of Medical ozone injection in Knee Osteoarthritis, sponsored by Gaziler Physical Medicine and Rehabilitation Education and Research Hospital.

What drugs are being tested in NCT04830423?

Interventions in NCT04830423: Medical ozone injection, steroid injection group.

What condition does NCT04830423 study?

NCT04830423 studies Knee Osteoarthritis.

Is NCT04830423 still recruiting?

NCT04830423 is currently status unknown. Last updated 16 March 2022.

Last reviewed 2022-03-16 · How we verify

NCT04830423

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Effectiveness of Ultrasound Guided Ozone (O2-O3) Injection With Knee Osteoarthritis

Status unknown NA Last updated 16 March 2022

What this trial tests

NA trial testing Medical ozone injection in Knee Osteoarthritis in 96 participants. Status unknown.

Timeline

15 April 2021

Primary endpoint
15 April 2022

15 April 2022

Quick facts

Lead sponsor	Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	96
Start date	15 April 2021
Primary completion	15 April 2022
Estimated completion	15 April 2022
Sites	1 location across Turkey (Türkiye)

Drugs / interventions tested

Medical ozone injection
steroid injection group

Conditions studied

Knee Osteoarthritis — all drugs for Knee Osteoarthritis →

Sponsor

Gaziler Physical Medicine and Rehabilitation Education and Research Hospital

Who can join

Adults 45 to 75, any sex, with Knee Osteoarthritis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Knee ostheoarthritis (KOA) is a common disabling and degenerative disease leading to painful joints, articular stiffness, and decreased function. The mechanism of the ozone of relieving the pain and improving the knee function is through inhibiting the inflammation reaction in the KOA directly. Actually, the ozone intra-articular injection had been used to relieve the pain caused by KOA. The aim of this study is to evaluate the effect of intra-articular injection of medical ozone given into the knee of the osteoarthritis patients, and to compare it with intra-articular steroid injection and to investigate the effectiveness of ozone and steroid the job to determine the superiority of the injections to each other.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

The efficacy of ultrasonography-guided oxygen-ozone therapy versus corticosteroids in patients with knee osteoarthritis: A multicenter randomized controlled trial.
Aslan SG, de Sire A, Köylü SU, Tezen Ö, et al · · 2024 · cited 7× · PMID 39240624 · DOI 10.3233/bmr-240023
Ozone therapy for knee osteoarthritis: a literature visualization analysis of research hotspots and prospects.
Liu Q, Liu J, Cao G, Liu Y, et al · · 2025 · cited 5× · PMID 39648327 · DOI 10.4103/mgr.medgasres-d-24-00099

Verify or expand the search:

Other recruiting trials for Knee Osteoarthritis

Currently open trials in the same condition.

NCT06906939 — A Randomized Pilot rTMS Trial for Knee Arthritis Pain and Depression · EARLY_PHASE1 · recruiting
NCT05823727 — Effects of Collagen Peptide Supplementation on Connective Tissue Remodeling, Functional Outcomes, and Wound Healing Afte · NA · recruiting
NCT07370480 — Knee Osteoarthritis and Thermal Spa Treatment · NA · recruiting
NCT07507175 — Gastrocnemius Myofascial Release in Females With Knee Osteoarthritis · NA · recruiting
NCT07386600 — Dexamethasone vs Dexmedetomidine for iPACK + ACB in TKA · NA · recruiting

Other Gaziler Physical Medicine and Rehabilitation Education and Research Hospital trials

Trials by the same sponsor.

NCT07207694 — WhatsApp-Based Education Program for Stroke Patients · NA · not yet recruiting
NCT07472543 — Impact of Virtual Reality (VR) Based Exercises on Lower Limb Lymphedema Outcomes (LELO) · NA · recruiting
NCT07507357 — Tidal Model Nursing for TBI Caregivers · NA · completed
NCT07059468 — Osteoporosis After Stroke · completed
NCT06917027 — Comparison of Mobile Education and Face-to-Face Intermittent Catheterization Education · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04830423 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Last refreshed: 16 March 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04830423.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing