NCT04827368 (VOC) is a clinical trial of Breath Test in IBD, sponsored by The Cleveland Clinic.

Who is sponsoring NCT04827368?

NCT04827368 is sponsored by The Cleveland Clinic.

What drugs are being tested in NCT04827368?

Interventions in NCT04827368: Breath Test.

What condition does NCT04827368 study?

NCT04827368 studies IBD, Crohn Disease, Ulcerative Colitis.

Is NCT04827368 still recruiting?

NCT04827368 is currently active, enrolled. Last updated 16 July 2025.

Last reviewed 2025-07-16 · How we verify

NCT04827368: VOC

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Volatile Organic Compounds (VOCs) in Active Inflammatory Bowel Disease

Active, enrolled Last updated 16 July 2025

What this trial tests

trial testing Breath Test in IBD in 292 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

22 March 2021

Primary endpoint
30 June 2026

30 June 2026

Quick facts

Lead sponsor	The Cleveland Clinic
Status	Active, enrolled
Study type	OBSERVATIONAL
Enrollment	292
Start date	22 March 2021
Primary completion	30 June 2026
Estimated completion	30 June 2026
Sites	1 location across United States

Drugs / interventions tested

Breath Test

Conditions studied

IBD — all drugs for IBD →
Crohn Disease — all drugs for Crohn Disease →
Ulcerative Colitis — all drugs for Ulcerative Colitis →

Sponsor

The Cleveland Clinic

Who can join

Adults 18 to 70, any sex, with IBD or Crohn Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Inflammatory Bowel Disease (IBD) are chronic diseases of the gut comprising Crohn's Disease (CD) and Ulcerative Colitis (UC). The symptoms of IBD consist of diarrhea, abdominal discomfort, weight loss, fatigue and rectal bleeding. However, symptoms and treatment vary between patients. Early management of IBD can lead to better response rates and decrease the risk of irreversible bowel damage and future disease complications such as surgeries. Current clinical tools for diagnosis and or assessing progression of IBD are either invasive (colonoscopy), have low patient acceptance (fecal calprotectin) or low accuracy (C-reactive protein). The purpose of this study is to collect clinical data and samples (including blood, breath and stool) donated by patients with IBD and patients with no IBD (controls) to facilitate research that may result in the development of new non-invasive methods of diagnosing IBD and understand the progression of the disease over time in order to better manage IBD patients.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

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Trials testing the same drug.

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Other recruiting trials for IBD

Currently open trials in the same condition.

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NCT07224113 — Assessment and Educational Intervention to Reduce Ultra-processed Food Consumption in Pediatric Patients With IBD · recruiting
NCT07195123 — Evaluation of the SMART IBD App in Pediatric IBD · NA · recruiting
NCT07380022 — Acceptability, Adherence, and Impact on the Bioavailability of Iron and Zinc of the Dietary Supplements Goodphyte IB Def · NA · recruiting

Other The Cleveland Clinic trials

Trials by the same sponsor.

NCT07218198 — Clinical Decision Support Tool for the Treatment of Uncontrolled Hypertension · NA · not yet recruiting
NCT07442747 — Neural Mechanisms of Aerobic Exercise Benefits in PD With DBS · NA · not yet recruiting
NCT07471464 — Centered Surgery - Preoperative Counseling and Patient Satisfaction · recruiting
NCT07073963 — Virtual Patient Groups for Sarcoidosis Associated Fatigue · NA · recruiting
NCT07363343 — Nifedipine and Enalapril vs Nifedipine and Labetalol for the Treatment of Postpartum Hypertension Study · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04827368 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by The Cleveland Clinic
Last refreshed: 16 July 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04827368.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing