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NCT04827238
Standardized Invasive Hemodynamics for Elevated Gradients Post TAVR (DISCORDANCE TAVR)
trial testing Standardized Invasive Hemodynamics in Aortic Stenosis in 49 participants. Completed in 20 June 2025.
20 June 2025
Quick facts
| Lead sponsor | University of British Columbia |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 49 |
| Start date | 30 August 2021 |
| Primary completion | 20 June 2025 |
| Estimated completion | 20 June 2025 |
| Sites | 9 locations across Canada, United States |
Drugs / interventions tested
- Standardized Invasive Hemodynamics
Conditions studied
- Aortic Stenosis — all drugs for Aortic Stenosis →
- Aortic Valve Stenosis — all drugs for Aortic Valve Stenosis →
Sponsor
University of British Columbia
Who can join
Eligibility, any sex, with Aortic Stenosis or Aortic Valve Stenosis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The DISCORDANCE TAVR study will determine the discordance between echocardiography-derived and invasive transaortic gradients, as determined by a consistent and reproducible technique (Standardized Invasive Hemodynamics) post-TAVR.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Prognostic value of invasive versus echocardiography-derived aortic gradient in patients undergoing TAVI.
van den Dorpel MMP, Chatterjee S, Adrichem R, Verhemel S, et al · · 2025 · cited 5× · PMID 40259836 · DOI 10.4244/eij-d-24-00341 -
TAVI vs SAVR: The timeless showdown in aortic valve replacement.
Baudo M. · · 2025 · PMID 39897417 · DOI 10.1016/j.ijcha.2025.101608
Verify or expand the search:
- PubMed search for NCT04827238
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04827238 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of British Columbia
- Last refreshed: 24 July 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04827238.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing