Who is sponsoring NCT04826575?

NCT04826575 is sponsored by St. Anne's University Hospital Brno, Czech Republic.

What drugs are being tested in NCT04826575?

Interventions in NCT04826575: High intensity inspiratory and expiratory muscle training.

What condition does NCT04826575 study?

NCT04826575 studies Lung Cancer, Post-Op Complication.

Is NCT04826575 still recruiting?

NCT04826575 is currently completed. Last updated 15 May 2025.

Last reviewed 2025-05-15 · How we verify

NCT04826575

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Pre-habilitation in Lung Surgery Candidates

Completed NA Last updated 15 May 2025

What this trial tests

NA trial testing High intensity inspiratory and expiratory muscle training in Lung Cancer in 150 participants. Completed in 31 December 2024.

Timeline

25 March 2021

Primary endpoint
31 December 2024

31 December 2024

Quick facts

Lead sponsor	St. Anne's University Hospital Brno, Czech Republic
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	prevention
Enrollment	150
Start date	25 March 2021
Primary completion	31 December 2024
Estimated completion	31 December 2024
Sites	3 locations across Czechia

Drugs / interventions tested

High intensity inspiratory and expiratory muscle training

Conditions studied

Lung Cancer — all drugs for Lung Cancer →
Post-Op Complication — all drugs for Post-Op Complication →

Sponsor

St. Anne's University Hospital Brno, Czech Republic

Who can join

18 and older, any sex, with Lung Cancer or Post-Op Complication. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

We hypothesize that high intensity respiratory muscle training will improve ventilatory efficiency (VE/VCO2 slope) and will be associated with decreased PPC, decreased mortality and better quality of life in lung resection candidates. Accordingly, the aim of this study will be to compare rest and exercise ventilation and gas exchange parameters as well as postoperative complications, quality of life and mortality in patients who undergo high intensity respiratory muscle training compared to patients who receive the usual standard of care.

Publications & conference data

6 peer-reviewed publications reference this trial (live from Europe PMC):

Multimodal prehabilitation before lung resection surgery: a multicentre randomised controlled trial.
Brat K, Sova M, Homolka P, Plutinsky M, et al · · 2025 · cited 10× · PMID 40374400 · DOI 10.1016/j.bja.2025.03.018
Causes of ventilatory inefficiency in lung resection candidates.
Bartos S, Svoboda M, Brat K, Lukes M, et al · · 2025 · cited 2× · PMID 40129541 · DOI 10.1183/23120541.00792-2024
New models for prediction of postoperative pulmonary complications in lung resection candidates.
Svoboda M, Cundrle I, Plutinsky M, Homolka P, et al · · 2024 · cited 2× · PMID 39286055 · DOI 10.1183/23120541.00978-2023
Cardiopulmonary exercise testing before lung resection surgery: still indicated? Evaluating predictive utility using machine learning.
Filakovszky Á, Brat K, Tschoellitsch T, Bartos S, et al · · 2026 · cited 1× · PMID 41043965 · DOI 10.1136/thorax-2024-221485
Hyperoxemia post thoracic surgery - Does it matter?
Brat K, Chovanec Z, Mitas L, Sramek V, et al · · 2023 · cited 1× · PMID 37416669 · DOI 10.1016/j.heliyon.2023.e17606
Circadian variation of post-operative complications in lung resection surgery.
Lukes M, Brat K, Hruda J, Chovanec Z, et al · · 2026 · PMID 42245833 · DOI 10.3389/fphys.2026.1818583

Verify or expand the search:

Other recruiting trials for Lung Cancer

Currently open trials in the same condition.

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NCT07524114 — Study of High-Precision Evaluation of Molecular ResiduaL Disease Through a PlatfOrm for Cancer TracKing and Interception · recruiting
NCT07487064 — Galvanize Aliya® EX Pulsed Electric Field (PEF) Treat and Resect Study · NA · recruiting
NCT07146568 — Evaluating the Implementation and Effectiveness of the Pink and Pearl Campaign on Lung Cancer Screening at Christian Hos · NA · recruiting

Other St. Anne's University Hospital Brno, Czech Republic trials

Trials by the same sponsor.

NCT07315542 — Diagnostic and Therapeutic Targets in Cartilaginous Tumours · recruiting
NCT06989229 — The Effect of Perioperative Nutritional Care on Recovery After Knee and Hip Replacement Surgery · recruiting
NCT06579274 — Evaluation of the Safety and Efficacy of Parecoxib in Patients With Subarachnoid Hemorrhage · Phase 2 · not yet recruiting
NCT06702059 — Cardiopulmonary Exercise Testing in Cardiosurgery Patients · recruiting
NCT05861089 — Rest PETCO2 As a Predictor of Post-operative Complications · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04826575 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by St. Anne's University Hospital Brno, Czech Republic
Last refreshed: 15 May 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04826575.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing