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NCT04825522
The Effect of Intrawound Vancomycin Powder in Spine Surgery
Phase 4 trial testing Vancomycin in Spine Disease in 1,643 participants. Currently enrolling.
1 December 2028
Quick facts
| Lead sponsor | Windsor-Essex Compassionate Care Community |
|---|---|
| Phase | Phase 4 |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | prevention |
| Enrollment | 1,643 |
| Start date | 27 March 2022 |
| Primary completion | 1 December 2028 |
| Estimated completion | 1 December 2028 |
| Sites | 2 locations across Canada, Egypt |
Drugs / interventions tested
- Vancomycin (vancomycin) — full drug profile →
Conditions studied
- Spine Disease — all drugs for Spine Disease →
Sponsor
Windsor-Essex Compassionate Care Community
Who can join
18 and older, any sex, with Spine Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Problem: Postoperative wound infection following various spinal surgeries is a serious complication. The incidence of post-surgical wounds in spine surgery is high, and various researchers have reported different infection rates. In addition, increased healthcare costs, prolonged lengths of stay in hospital, and reduced quality of life as a result of surgical site infections (SSI) are also major concerns. Several methods for avoiding SSI, such as betadine irrigation, vacuum-assisted closure, and intra-wound vancomycin powder, have been used to reduce the rate of wound infection in spine surgery. Use of local vancomycin has been popular because of its protective effects and lower cost. According to some reports, prophylactic administration of intra-wound vancomycin powder before wound closure is an effective method for decreasing postoperative wound infection rates; however, other studies have revealed a non-significant effect of intra-wound vancomycin use for decreasing the postsurgical wound infection rate. Solution: Therefore, the investigators will prospectively randomize all various types of spinal surgeries to patients who will receive intrawound vancomycin powder and control group who will not receive the powder and to see it's effect in reducing the post-surgical infection.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT04825522
- Europe PMC full search
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Related trials
Other trials of Vancomycin
Trials testing the same drug.
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- NCT06567808 — Prevention of Infections in Cardiac Surgery (PICS): a Cluster-randomized Factorial Cross-over Trial · Phase 4 · not yet recruiting
- NCT06702345 — Clostridioides Difficile Controlled Human Infection Model · NA · not yet recruiting
- NCT06716749 — Effectiveness of Adding Morphine to Intraosseous Vancomycin for Pain Control in Total Knee Arthroplasty · Phase 2 · completed
- NCT06439953 — Irrisept Solution for Instrumented Spine Surgery · NA · recruiting
Other recruiting trials for Spine Disease
Currently open trials in the same condition.
- NCT07180940 — Comparison of Perineural Dexamethasone Versus Dexmedetomidine as Adjuvants to Erector Spinae Plane Block in Lumbar Spine · Phase 4 · recruiting
- NCT06835634 — Progressive Advancements in Neurosurgery, Data and Analysis Database · active not recruiting
- NCT07017985 — Prevalence of Diabetes in Patients Who Are Candidates for Spine Surgery · recruiting
- NCT06233617 — Dexamethasone vs. Dexmedetomidine for ESPB in Pain Management After Spine Surgery · Phase 4 · recruiting
- NCT06400680 — Gait Spine Functional Evaluation Protocol · NA · active not recruiting
Other Windsor-Essex Compassionate Care Community trials
Trials by the same sponsor.
- NCT05070078 — The Single Assessment Numeric Evaluation (SANE) for Lumbar Discectomy · recruiting
- NCT03263169 — Community-based Personalized Care and QOL · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04825522 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Windsor-Essex Compassionate Care Community
- Last refreshed: 23 April 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04825522.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing