NCT04824599 is a NA clinical trial of PECS II in Breast Neoplasm, sponsored by Karlstad Central Hospital.

Who is sponsoring NCT04824599?

NCT04824599 is sponsored by Karlstad Central Hospital.

What drugs are being tested in NCT04824599?

Interventions in NCT04824599: PECS II, Local anesthetic infiltration, Subcutaneus local anesthetic infiltration, Ropivacaine, bk medical Flex Focus 500 Ultrasound Machine.

What condition does NCT04824599 study?

NCT04824599 studies Breast Neoplasm.

Is NCT04824599 still recruiting?

NCT04824599 is currently completed. Last updated 7 September 2023.

Last reviewed 2023-09-07 · How we verify

NCT04824599

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Regional Anesthesia and Partial Mastectomy

Completed NA Last updated 7 September 2023

What this trial tests

NA trial testing PECS II in Breast Neoplasm in 60 participants. Completed in 1 May 2022.

Timeline

19 February 2021

Primary endpoint
1 May 2022

1 May 2022

Quick facts

Lead sponsor	Karlstad Central Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	prevention
Enrollment	60
Start date	19 February 2021
Primary completion	1 May 2022
Estimated completion	1 May 2022
Sites	1 location across Sweden

Drugs / interventions tested

PECS II
Local anesthetic infiltration — full drug profile →
Subcutaneus local anesthetic infiltration
Ropivacaine (ROPIVACAINE) — full drug profile →
bk medical Flex Focus 500 Ultrasound Machine

Conditions studied

Breast Neoplasm — all drugs for Breast Neoplasm →

Sponsor

Karlstad Central Hospital

Who can join

18 and older, female only, with Breast Neoplasm. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Pectoralis nerves plane block (PECS) first described by Blanco in 2011 has become part of postoperative pain management in breast surgery, thoracic surgery and thoracic trauma. The combination of low complication risk and easiness in mastering of PECS block has made it an interesting alternative to thoracic epidural anesthesia (TEDA) and paravertebral blockade (PVB) for pain treatment after breast surgery. Several studies showed good results when PECS was compared to PVB. PECS blockade however is a procedure requiring some resources in the operating room. An alternative approach is to inject local anesthetics (LA) in the operation field by the surgeon. The hypothesis' tested in this study is primarily: that PECS blockade is superior to LA being injected by surgeon in the operating field measured by end points such as: post-operative pain, post-operative analgesics use, post-operative nausea or vomiting (PONV) and length of stay in the post anesthesia care unit (PACU).

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Interpectoral and Pectoserratus Plane Block vs. Local Anesthetic Infiltration for Partial Mastectomy: A Prospective Randomized Trial.
Eisler P, Zimmermann S, Henningsson R. · · 2024 · cited 1× · PMID 38550709 · DOI 10.1155/2024/9989997

Verify or expand the search:

Other recruiting trials for Breast Neoplasm

Currently open trials in the same condition.

NCT07054723 — Surviving Daily Life · recruiting
NCT06839001 — CRYoablation for Small Tumors As Local Treatment - SIX Trial · Phase 3 · recruiting
NCT06672302 — A Prospective Study to Develop and Clinically Validate an in Vitro Diagnostic Medical Device That Uses Blood to Classify · recruiting
NCT06255808 — Development of Assist Tool for Breast Examination Using the Principle of Ultrasonic Sensor · active not recruiting
NCT06622967 — KNUCH CadAI-B-1(KCB-1) · NA · active not recruiting

Other Karlstad Central Hospital trials

Trials by the same sponsor.

NCT06336746 — Cardiac Performance During Steep Trendelenburg Position in Patients Undergoing Robotic Surgery Surgery. · recruiting
NCT05602662 — Music as a Complement to Pharmacological Sedation in Ventilator Treated ICU Patients. · NA · recruiting
NCT04675840 — Intrathecal Morphine for Robotic-assisted Laparoscopic Hysterectomy. · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04824599 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Karlstad Central Hospital
Last refreshed: 7 September 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04824599.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing