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NCT04823793
Fecal DNA Methylation Test for Colorectal Cancer Screening
trial testing Stool DNA methylation detection in Colorectal Cancer in 80 participants. Status unknown.
20 March 2023
Quick facts
| Lead sponsor | Tri-Service General Hospital |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 80 |
| Start date | 31 March 2021 |
| Primary completion | 20 March 2023 |
| Estimated completion | 20 March 2023 |
| Sites | 1 location across Taiwan |
Drugs / interventions tested
- Stool DNA methylation detection
Conditions studied
- Colorectal Cancer — all drugs for Colorectal Cancer →
- Colorectal Adenoma — all drugs for Colorectal Adenoma →
Sponsor
Tri-Service General Hospital
Who can join
Adults 40 to 79, any sex, with Colorectal Cancer or Colorectal Adenoma. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This is an observational, prospective study using fecal DNA methylation test to define the risk of suffering from advanced adenoma or colorectal cancer (CRC) compared to colonoscopy and fecal immunochemical test (FIT). This study recruits at least 80 participants, including 40 people of healthy controls, 20 people with adenoma, and 20 people with CRC, which were confirmed by colonoscopy. All fecal specimens from participants will be examined by FIT and multi-methylated target gene detection through real-time quantitative methylation-specific PCR (qMSP). The objective of this study is to evaluate the sensitivity and specificity of multi-methylated target PCR compared with the FIT and confirm the examination results through colonoscopy.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Diagnostic and therapeutic biomarkers in colorectal cancer: a review.
de Assis JV, Coutinho LA, Oyeyemi IT, Oyeyemi OT, et al · · 2022 · cited 23× · PMID 35261794 -
Using Comorbidity Pattern Analysis to Detect Reliable Methylated Genes in Colorectal Cancer Verified by Stool DNA Test.
Cheng YC, Wu PH, Chen YJ, Yang CH, et al · · 2021 · cited 9× · PMID 34680934 · DOI 10.3390/genes12101539
Verify or expand the search:
- PubMed search for NCT04823793
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04823793 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Tri-Service General Hospital
- Last refreshed: 8 April 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04823793.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing