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NCT04822246: ART-AIRFLOW
Excavation of Root Caries with Air-water Powder Stream Vs Manual Excavation for Atraumatic Restorative Treatment in Older Patients: a Single-blind Randomized Controlled Trial
NA trial testing Control: Hand instrumentation for caries excavation in Dental Caries Extending Into Dentin in 62 participants. Participants enrolled and being followed up; not accepting new ones.
1 September 2025
Quick facts
| Lead sponsor | Murali Srinivasan, Dr. med. dent., BDS, MDS, MBA, MAS |
|---|---|
| Phase | NA |
| Status | Active, enrolled |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 62 |
| Start date | 30 September 2021 |
| Primary completion | 1 September 2025 |
| Estimated completion | 31 December 2025 |
| Sites | 1 location across Switzerland |
Drugs / interventions tested
- Control: Hand instrumentation for caries excavation
- Intervention 1: EMS Airflow device for caries excavation
- Intervention 2: Hand excavation + EMS Airflow device for caries excavation
Conditions studied
- Dental Caries Extending Into Dentin — all drugs for Dental Caries Extending Into Dentin →
- Root Caries — all drugs for Root Caries →
Sponsor
Murali Srinivasan, Dr. med. dent., BDS, MDS, MBA, MAS
Who can join
65 and older, any sex, with Dental Caries Extending Into Dentin or Root Caries. Healthy volunteers can join.
What's being measured
Primary outcomes are the specific endpoints the trial is designed to prove or disprove.
-
Restoration Success rate
Time frame: 1 year, year 1
Restoration success rate (SxR %): For the purpose of this trial, a successful restoration is defined as one that has undergone no changes in its surface / structural integrity, still adhered to the structure and is functional when examined during the scheduled or unscheduled recall visit. The restoration success rate (SxR %) is calculated by the number of successful restorations present at the end -
Restoration survival rate
Time frame: 1 year, year 1
Restoration survival rate (SvR %): For the purpose of this trial, any restoration, where the surface or structural integrity is compromised, but still adhering to the tooth, is functional and does not warrant a repair or replacement when examined during the scheduled or unscheduled recall visit, is considered survived. The restoration survival rate (SvR %) is calculated by the number of survived r
Sponsor's own description
The main objective of this RCT is to compare the efficacy of a powder/water jet prophylaxis device and conventional hand excavation in excavating root surface caries, with regard to restoration survival/success in older adults. The secondary outcome of this RCT is to assess the participants' treatment preferences for the received treatment with regard to the procedures involved and in the invasiveness of the procedures carried out during the ART restoration.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT04822246
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04822246 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Murali Srinivasan, Dr. med. dent., BDS, MDS, MBA, MAS
- Last refreshed: 3 December 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04822246.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing