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NCT04814407
Developing Novel Circulating Epigenetic Biomarkers for Early Detection of Lung Cancer
trial testing Blood-derived DNA methylation detection in Lung Cancer in 900 participants. Currently enrolling.
31 December 2025
Quick facts
| Lead sponsor | National Taiwan University Hospital |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 900 |
| Start date | 1 March 2021 |
| Primary completion | 31 December 2025 |
| Estimated completion | 31 December 2027 |
| Sites | 1 location across Taiwan |
Drugs / interventions tested
- Blood-derived DNA methylation detection
Conditions studied
- Lung Cancer — all drugs for Lung Cancer →
Sponsor
National Taiwan University Hospital
Who can join
20 and older, any sex, with Lung Cancer. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The investigators aim to identify novel circulating methylated biomarkers for early lung cancer detection as well as to develop new technologies that are clinically applicable with high sensitivity and specificity.
Publications & conference data
6 peer-reviewed publications reference this trial (live from Europe PMC):
-
Advances in lung cancer screening and early detection.
Li C, Wang H, Jiang Y, Fu W, et al · · 2022 · cited 61× · PMID 35535966 · DOI 10.20892/j.issn.2095-3941.2021.0690 -
Liquid Biopsy to Detect Minimal Residual Disease: Methodology and Impact.
Honoré N, Galot R, van Marcke C, Limaye N, et al · · 2021 · cited 50× · PMID 34771526 · DOI 10.3390/cancers13215364 -
Clinical Utility of Liquid Biopsy-Based Actionable Mutations Detected via ddPCR.
Palacín-Aliana I, García-Romero N, Asensi-Puig A, Carrión-Navarro J, et al · · 2021 · cited 38× · PMID 34440110 · DOI 10.3390/biomedicines9080906 -
Epigenomic Echoes-Decoding Genomic and Epigenetic Instability to Distinguish Lung Cancer Types and Predict Relapse.
Baumann AA, Buribayev Z, Wolkenhauer O, Salybekov AA, et al · · 2025 · cited 5× · PMID 39982247 · DOI 10.3390/epigenomes9010005 -
Revolution of Circulating Tumor DNA: From Bench Innovations to Bedside Implementations.
Yan X, Su J, Wang Z. · · 2025 · cited 1× · PMID 40699826 · DOI 10.3390/cimb47060428 -
DNA Methylation in Lung Cancer: Predictive Biomarkers for Effective Immunotherapy.
Kumari K, Kumar V, Verma C, Hsu PC, et al · · 2025 · PMID 41497171 · DOI 10.2147/ijgm.s552594
Verify or expand the search:
- PubMed search for NCT04814407
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other National Taiwan University Hospital trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04814407 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by National Taiwan University Hospital
- Last refreshed: 18 June 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04814407.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing