NCT04810871 is a NA clinical trial of Brain Surgery in Brain Neoplasm, sponsored by Mayo Clinic.

Who is sponsoring NCT04810871?

NCT04810871 is sponsored by Mayo Clinic.

What drugs are being tested in NCT04810871?

Interventions in NCT04810871: Brain Surgery.

What condition does NCT04810871 study?

NCT04810871 studies Brain Neoplasm.

Is NCT04810871 still recruiting?

NCT04810871 is currently suspended. Last updated 30 January 2026.

Last reviewed 2026-01-30 · How we verify

NCT04810871

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Surgical Resection of Latent Brain Tumors Prior to Recurrence

Suspended NA Last updated 30 January 2026

What this trial tests

NA trial testing Brain Surgery in Brain Neoplasm in 40 participants. Suspended.

Timeline

6 May 2021

Primary endpoint
1 March 2028

1 March 2028

Quick facts

Lead sponsor	Mayo Clinic
Phase	NA
Status	Suspended
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	40
Start date	6 May 2021
Primary completion	1 March 2028
Estimated completion	1 March 2028
Sites	1 location across United States

Drugs / interventions tested

Brain Surgery

Conditions studied

Brain Neoplasm — all drugs for Brain Neoplasm →

Sponsor

Mayo Clinic

Who can join

18 and older, any sex, with Brain Neoplasm. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This clinical trial evaluates the side effects and possible benefits of operating on brain tumors prior to the tumor coming back (recurrence). Understanding when surgery is most useful to patients with brain tumors is important. Some patients may undergo chemotherapy or radiation but still have visible tumor remaining after treatment. The purpose of this research is to compare outcomes of those who have surgery after chemotherapy or radiation, but prior to tumor recurrence, to those who have surgery at a different time, or no surgery at all.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

A brave new framework for glioma drug development.
Hotchkiss KM, Karschnia P, Schreck KC, Geurts M, et al · · 2024 · cited 23× · PMID 39362262 · DOI 10.1016/s1470-2045(24)00190-6
An untapped window of opportunity for glioma: targeting therapy-induced senescence prior to recurrence.
Riviere-Cazaux C, Carlstrom LP, Neth BJ, Olson IE, et al · · 2023 · cited 19× · PMID 38030881 · DOI 10.1038/s41698-023-00476-8
Cerebrospinal fluid cell-free DNA as a liquid biopsy tool for detecting and monitoring genomic alterations in thalamic colorectal cancer metastases.
Gharibi Loron A, Ha Y, Riviere-Cazaux C, Wang X, et al · · 2025 · PMID 41323961 · DOI 10.1093/noajnl/vdaf178

Verify or expand the search:

Other trials of Brain Surgery

Trials testing the same drug.

NCT06650163 — Zr-89 Crefmirlimab Berdoxam and Immuno-Positron Emission Tomography for the Imaging of Patients With Resectable Brain Tu · Phase 1 · recruiting
NCT05438212 — Comparing the Addition of Radiation Either Before or After Surgery for Patients With Brain Metastases · Phase 3 · active not recruiting
NCT04474925 — Pre- Versus Post-operative SRS for Resectable Brain Metastases · Phase 3 · terminated

Other recruiting trials for Brain Neoplasm

Currently open trials in the same condition.

NCT04553757 — Seizure Control as a New Metric in Assessing Efficacy of Tumor Treatment in Patients With Low Grade Glioma · active not recruiting
NCT05087888 — MRI and Blood Biomarkers for the Prediction of Neurocognitive Decline Following Brain Radiation · active not recruiting
NCT03606161 — Navigated Repetitive Transcranial Magnetic Stimulation in Improving Motor Rehabilitation in Participants With Brain Tumo · NA · active not recruiting
NCT02754544 — Electrocorticography in Mapping Functional Brain Areas During Surgery in Patients With Brain Tumors · NA · recruiting
NCT02639325 — Tumor Related Epilepsy · recruiting

Other Mayo Clinic trials

Trials by the same sponsor.

NCT07126548 — A Point of Prostate Cancer Diagnosis Virtual Reality Assistant Intervention in Supporting Newly Diagnosed Black Men · NA · not yet recruiting
NCT07221656 — Evaluation of Prolonged Asparaginase Activity Levels After Calaspargase Pegol Administration · not yet recruiting
NCT06891001 — The Utilization of a Shoe Insert on Individuals With Unilateral Greater Trochanteric Pain Syndrome on Single Leg Stance, · NA · not yet recruiting
NCT07169799 — Impact of Cryotherapy Spray (Tru-Freeze) for the Eradication of Gastric Antral Vascular Ectasia (ICE-GAVE) · NA · recruiting
NCT07086183 — Perioperative Risk in Patients on Chronic Aspirin Undergoing Craniotomy · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04810871 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Mayo Clinic
Last refreshed: 30 January 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04810871.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing