Last reviewed · How we verify
NCT04807738: VIREMS
Virtual Reality in Physical Therapy in Multiple Sclerosis
NA trial testing Neuroproprioceptive "facilitation and inhibition" in virtual reality in Multiple Sclerosis in 71 participants. Completed in 1 February 2025.
2 January 2025
Quick facts
| Lead sponsor | Charles University, Czech Republic |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | supportive care |
| Enrollment | 71 |
| Start date | 1 April 2021 |
| Primary completion | 2 January 2025 |
| Estimated completion | 1 February 2025 |
| Sites | 2 locations across Czechia |
Drugs / interventions tested
- Neuroproprioceptive "facilitation and inhibition" in virtual reality
- Neuroproprioceptive "facilitation and inhibition"
Conditions studied
- Multiple Sclerosis — all drugs for Multiple Sclerosis →
Sponsor
Charles University, Czech Republic
Who can join
Adults 18 to 75, any sex, with Multiple Sclerosis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The randomized controlled trial is aimed to study the efficacy of virtual reality (VR) and its impact on upper limb function and postural stability in people with mild to severe multiple sclerosis (pwMS). The conceptual idea is to compare two kinds of neuroproprioceptive "facilitation and inhibition" physical therapy, first in a real environment and second in virtual reality, in out-patient therapy that will be held in 15 hourly therapies, 2x a week in a period of two months. The efficacy will be assessed by a blinded independent clinical examiner using clinical examination and questionnaire survey before and in a week following the therapeutic intervention. The main focus is on upper limb gross and fine motor skills, trunk stability and stability, and sit to stand stability.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Virtual reality-based neuroproprioceptive physiotherapy in multiple sclerosis: a protocol for a double-arm randomised assessor-blinded controlled trial on upper extremity function, postural function and quality of life, with molecular and functional MRI assessment.
Miznerova B, Reissigova J, Vasa L, Frank J, et al · · 2025 · cited 1× · PMID 39788766 · DOI 10.1136/bmjopen-2024-088046
Verify or expand the search:
- PubMed search for NCT04807738
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Other Charles University, Czech Republic trials
Trials by the same sponsor.
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- NCT07512570 — Feasibility and Preliminary Effects of a Structured Resistance Training Program in Children Aged 10-14 Years · NA · not yet recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04807738 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Charles University, Czech Republic
- Last refreshed: 7 March 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04807738.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing