NCT04806321 is a NA clinical trial of Project SOLVE in Anxiety, sponsored by Harvard University.

Who is sponsoring NCT04806321?

NCT04806321 is sponsored by Harvard University.

What drugs are being tested in NCT04806321?

Interventions in NCT04806321: Project SOLVE, Project SUCCESS.

What condition does NCT04806321 study?

NCT04806321 studies Anxiety, Depression, Stress.

Is NCT04806321 still recruiting?

NCT04806321 is currently completed. Last updated 11 July 2022.

Last reviewed 2022-07-11 · How we verify

NCT04806321

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Project SOLVE: Trial of a Brief Digital Problem-solving Intervention

Completed NA Last updated 11 July 2022

What this trial tests

NA trial testing Project SOLVE in Anxiety in 522 participants. Completed in 15 May 2022.

Timeline

15 March 2021

Primary endpoint
15 May 2022

15 May 2022

Quick facts

Lead sponsor	Harvard University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	prevention
Enrollment	522
Start date	15 March 2021
Primary completion	15 May 2022
Estimated completion	15 May 2022
Sites	1 location across United States

Drugs / interventions tested

Project SOLVE
Project SUCCESS

Conditions studied

Anxiety — all drugs for Anxiety →
Depression — all drugs for Depression →
Stress — all drugs for Stress →

Sponsor

Harvard University

Who can join

Adults 10 to 14, any sex, with Anxiety or Depression. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The goal of this trial is to examine the effectiveness of a universal, self-guided, digital single-session intervention focusing on problem-solving skills in improving adolescent mental health and well-being, relative to an active control intervention focusing on study skills, within the context of school settings during the coronavirus disease pandemic.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Is There a Place for Cognitive Restructuring in Brief, Self-Guided Interventions? Randomized Controlled Trial of a Single-Session, Digital Program for Adolescents.
Steinberg JS, Fitzpatrick OM, Khurana S, Kim MY, et al · · 2024 · cited 4× · PMID 39120779 · DOI 10.1080/15374416.2024.2384026

Verify or expand the search:

Other trials of Project SOLVE

Trials testing the same drug.

NCT06896071 — Evaluating a Digital Single-session Intervention for Adolescent Mental Health in New Zealand · NA · recruiting
NCT06064578 — The Ukrainian Student Problem Solving Project · NA · completed

Other recruiting trials for Anxiety

Currently open trials in the same condition.

NCT07336238 — Group Retreat Psilocybin Therapy for the Treatment of Anxiety and Depression in Patients With Metastatic Solid Tumors or · Phase 2 · recruiting
NCT07522944 — AI-Guided Relaxation for Hemodialysis Anxiety · NA · recruiting
NCT07466875 — Auricular Stimulation for Nicotine Withdrawal in Psychiatric Inpatients · NA · recruiting
NCT07425951 — Building Cognitive Behavioural Skills With StoryBooks to Reduce Emotional Difficulties in Kindergarten Years · NA · recruiting
NCT07473505 — Integrative Bilateral Cervical Sympathetic Blocks for Trauma-Related Symptoms in Special Operations Veterans: A Prospect · recruiting

Other Harvard University trials

Trials by the same sponsor.

NCT07316647 — Using Conversational AI to Teach Growth Mindset Skills to Youths in India · NA · completed
NCT06114862 — Brief Interventions on Social Media to Reduce Suicide Risk (Intervention 2) · NA · withdrawn
NCT07394465 — First Tones: Artistic Communal Practices for 4 and 5 Year Old Children · NA · completed
NCT06217705 — Testing the Effects of Project Calm in Ukrainian Schools · NA · completed
NCT06114875 — Brief Interventions on Social Media to Reduce Suicide Risk (Intervention 1) · NA · terminated

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04806321 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Harvard University
Last refreshed: 11 July 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04806321.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing