NCT04800055

Attractive Targeted Sugar Bait Phase III Trial in Zambia

Status unknown NA Last updated 18 November 2023

What this trial tests

NA trial testing Attractive Targeted Sugar Bait in Malaria in 3,480 participants. Status unknown.

Timeline

1 December 2020

Primary endpoint
31 July 2023

31 December 2023

Quick facts

Lead sponsor	PATH
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	prevention
Enrollment	3,480
Start date	1 December 2020
Primary completion	31 July 2023
Estimated completion	31 December 2023
Sites	1 location across Zambia

Drugs / interventions tested

• Attractive Targeted Sugar Bait

Conditions studied

• Malaria — all drugs for Malaria →
• Malaria,Falciparum — all drugs for Malaria,Falciparum →
• Vector-Borne Transmission of Infection — all drugs for Vector-Borne Transmission of Infection →

Sponsor

PATH — full company profile →

Who can join

Adults 12 Months to 15, any sex, with Malaria or Malaria,Falciparum. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The trial will evaluate the efficacy of ATSB deployment plus universal coverage of a WHO core vector control (VC) interventions over two transmission seasons on a minimum 30% reduction in cohort clinical disease incidence, confirmed case incidence, and parasite prevalence, as compared with VC alone. Measurement of entomological outcomes, assessment of acceptability and barriers to uptake and consistent use of ATSB, safety and adverse event monitoring and estimation of the cost and cost-effectiveness of ATSB will also occur.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. Attractive targeted sugar bait phase III trials in Kenya, Mali, and Zambia.
   Attractive Targeted Sugar Bait Phase III Trial Group. · · 2022 · cited 55× · PMID 35945599 · DOI 10.1186/s13063-022-06555-8
2. Entomological effects of attractive targeted sugar bait station deployment in Western Zambia: vector surveillance findings from a two-arm cluster randomized phase III trial.
   Wagman J, Chanda B, Chanda J, Saili K, et al · · 2024 · cited 15× · PMID 39026236 · DOI 10.1186/s12936-024-05045-3
3. Efficacy of attractive targeted sugar bait stations against malaria in Western Province Zambia: epidemiological findings from a two-arm cluster randomized phase III trial.
   Ashton RA, Saili K, Chishya C, Banda Yikona H, et al · · 2024 · cited 14× · PMID 39548456 · DOI 10.1186/s12936-024-05175-8
4. Residual bioefficacy of attractive targeted sugar bait stations targeting malaria vectors during seasonal deployment in Western Province of Zambia.
   Mwaanga G, Ford J, Yukich J, Chanda B, et al · · 2024 · cited 8× · PMID 38811947 · DOI 10.1186/s12936-024-04990-3
5. Why does malaria transmission continue at high levels despite universal vector control? Quantifying persistent malaria transmission by Anopheles funestus in Western Province, Zambia.
   Ashton RA, Chanda B, Chishya C, Muyabe R, et al · · 2024 · cited 7× · PMID 39402598 · DOI 10.1186/s13071-024-06457-5
6. Entomological Effects of Attractive Targeted Sugar Bait Station Deployment in Western Zambia: Vector Surveillance Findings from a Two-arm Cluster Randomized Phase III Trial
   Wagman J, Chanda B, Chanda J, Saili K, et al · · 2024 · cited 1× · DOI 10.21203/rs.3.rs-4450785/v1
7. Cost and cost-effectiveness of attractive targeted sugar baits (ATSB) in the context of a phase III cluster randomized control trial in Western Province, Zambia.
   Mancuso B, Orange E, Eisele TP, Ashton RA, et al · · 2025 · PMID 41420162 · DOI 10.1186/s12936-025-05716-9
8. Efficacy of Attractive Targeted Sugar Bait stations against malaria in Western Province Zambia: epidemiological findings from a two-arm cluster randomized Phase III trial
   Ashton RA, Saili K, Chishya C, Yikona HB, et al · · 2024 · DOI 10.21203/rs.3.rs-5187530/v1