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NCT04798144
Cryotherapy on Inflammatory Profile and Postoperative Pain Levels in Endodontic Infections
NA trial testing Distilled water irrigation kept at 2.5°C degree in Apical Periodontitis in 30 participants. Completed in 15 April 2022.
31 March 2022
Quick facts
| Lead sponsor | Ondokuz Mayıs University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 30 |
| Start date | 15 November 2020 |
| Primary completion | 31 March 2022 |
| Estimated completion | 15 April 2022 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- Distilled water irrigation kept at 2.5°C degree
- Distilled water irrigation kept at room temperature
Conditions studied
- Apical Periodontitis — all drugs for Apical Periodontitis →
- Postoperative Pain — all drugs for Postoperative Pain →
- Cytokine Levels — all drugs for Cytokine Levels →
Sponsor
Ondokuz Mayıs University
Who can join
Adults 20 to 30, male only, with Apical Periodontitis or Postoperative Pain. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aim of this study is to evaluate the effects of cryotherapy applications on the inflammatory cytokine and collagenase matrix metalloproteinase levels during root canal treatment and postoperative pain intensity and incidence. Mandibular premolar teeth of 60 male patients within the 20-30 years old range, diagnosed with asymptomatic apical periodontitis will be included to the study for this purpose. The experimental protocols consist clinical and laboratory phases. In clinical phase, procedures of cryotherapy and control groups will be applied in 2-visit-root canal treatment. The samples, which were collected during root canal treatment, will be subjected to enzyme-linked immunosorbent assay (ELISA) analysis in laboratory. Levels of interleukin and inflammatory destructive enzymes will be determined in collected samples. During the analysis of visual analogue scale scores, the correlation between the changes of the cytokine and proteolytic enzyme levels and presence and intensity of pain will be evaluated.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Effect of intracanal cryotherapy on the inflammatory cytokine, proteolytic enzyme levels and post-operative pain in teeth with asymptomatic apical periodontitis: A randomized clinical trial.
Keskin C, Aksoy A, Kalyoncuoğlu E, Keleş A, et al · · 2023 · cited 12× · PMID 37222468 · DOI 10.1111/iej.13937
Verify or expand the search:
- PubMed search for NCT04798144
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
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Related trials
Other recruiting trials for Apical Periodontitis
Currently open trials in the same condition.
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Other Ondokuz Mayıs University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04798144 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Ondokuz Mayıs University
- Last refreshed: 10 June 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04798144.
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