NCT04796610

Mopati: A Pilot Hiv Treatment Partner Intervention In Botswana

Completed NA Results posted Last updated 1 November 2023

What this trial tests

NA trial testing Mopati in HIV in 105 participants. Completed in 31 August 2022.

Timeline

17 June 2021

Primary endpoint
31 August 2022

31 August 2022

Quick facts

Lead sponsor	RAND
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	105
Start date	17 June 2021
Primary completion	31 August 2022
Estimated completion	31 August 2022
Sites	1 location across Botswana

Drugs / interventions tested

• Mopati

Conditions studied

• HIV — all drugs for HIV →

Sponsor

RAND — full company profile →

Who can join

18 and older, any sex, with HIV. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Viral Suppression of Patient Participants Primary · 6 months

Viral suppression will be defined as viral load \< 400 cp/ml

Group	Value	95% CI
Intervention Patients	12
Control Patients	13

Number of Patient Participants Self-Reported as Treatment Adherent Secondary · 3-months post-baseline

Participants self-reported the percentage of doses taken in the past month; we defined treatment adherence as having taken at least 95% of prescribed doses

Group	Value	95% CI
Intervention Patients	24
Control Patients	22

Perceived Treatment Partner Support Secondary · 3-months post-baseline

Continuous scores on Nondirective Support scale (0-5); higher = more nondirective support, rated by patient participants

Group	Value	95% CI
Intervention Patients	4.9	± 0.2
Control Patients	4.5	± 1.0

Sponsor's own description

This study is a pilot test of the Mopati program ("partner" in Setswana), which is a multi-level intervention that guides healthcare providers and patients about treatment partner selection, and trains treatment partners on provision of effective support. The Specific Aims are: (1) To develop a multi-level treatment partner intervention with input from community and healthcare provider stakeholders in Botswana; and (2) To conduct a pilot test of the feasibility, acceptability, and preliminary effects on viral suppression.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Pilot Test of Mopati, a Multi-Level Adherence Intervention for People Living with HIV and Their Treatment Partners in Botswana.
   Bogart LM, Phaladze N, Kgotlaetsile K, Klein DJ, et al · · 2024 · cited 8× · PMID 37957535 · DOI 10.1007/s12529-023-10233-7