Last reviewed · How we verify
NCT04794634: RETEVAL
Relationship Between Alzheimer Disease and Diminution of the Three Macular Nervous Retinal Layers
NA trial testing Optical coherence tomography (OCT) in Optical Coherence Tomography in 55 participants. Completed in 1 December 2025.
23 June 2023
Quick facts
| Lead sponsor | Centre Hospitalier Universitaire, Amiens |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 55 |
| Start date | 13 January 2021 |
| Primary completion | 23 June 2023 |
| Estimated completion | 1 December 2025 |
| Sites | 1 location across France |
Drugs / interventions tested
- Optical coherence tomography (OCT)
- Optical coherence tomograpohy angiography (OCTA)
Conditions studied
- Optical Coherence Tomography — all drugs for Optical Coherence Tomography →
- Optical Coherence Tomography Angiography — all drugs for Optical Coherence Tomography Angiography →
- Retinal Thickening — all drugs for Retinal Thickening →
- Alzheimer Disease — all drugs for Alzheimer Disease →
Sponsor
Centre Hospitalier Universitaire, Amiens
Who can join
18 and older, any sex, with Optical Coherence Tomography or Optical Coherence Tomography Angiography. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Alzheimer disease is hard, long and expensive to diagnose. In order to help the clinician, a new biomarker in Alzheimer disease seems to be very useful. The retina, as a window of the brain, could offer a new way to diagnose this common disease. Indeed, a retinal atrophy could especially appear in Alzheimer disease. Besides, many aspects about retinal alteration, visual function and their link with the disease deserve to be more explored. So as to fill these gaps, a new study about retinal specificity in Alzheimer disease appears to be relevant.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Retinal manifestations and their diagnostic significance in Alzheimer's disease.
Abhyankar SD, Little K, Stitt A, Bhatwadekar AD. · · 2025 · PMID 40799319 · DOI 10.1177/25424823251361937
Verify or expand the search:
- PubMed search for NCT04794634
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for Optical Coherence Tomography
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Other Centre Hospitalier Universitaire, Amiens trials
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04794634 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Centre Hospitalier Universitaire, Amiens
- Last refreshed: 8 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04794634.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing