Last reviewed · How we verify
NCT04793360: MAPLE
Molecular Assessment and Profiling of Liver Transplant Recipients
trial testing LiverCare in Liver Transplantation in 1,500 participants. Participants enrolled and being followed up; not accepting new ones.
31 December 2027
Quick facts
| Lead sponsor | CareDx |
|---|---|
| Status | Active, enrolled |
| Study type | OBSERVATIONAL |
| Enrollment | 1,500 |
| Start date | 26 May 2021 |
| Primary completion | 31 December 2027 |
| Estimated completion | 31 March 2028 |
| Sites | 26 locations across United States |
Drugs / interventions tested
- LiverCare
Conditions studied
- Liver Transplantation — all drugs for Liver Transplantation →
- Biomarkers — all drugs for Biomarkers →
Sponsor
CareDx — full company profile →
Who can join
12 and older, any sex, with Liver Transplantation or Biomarkers. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The objective of this protocol is to conduct longitudinal and prospective studies of liver transplant recipients, using a multimodality approach, akin to that used in kidney transplantation. The primary aim will compare the clinical outcomes of LiverCare post-transplant surveillance in liver transplant with standard of care consisting of liver function tests, DSA measurements, drug level monitoring, and 'for cause' biopsy. The protocol will assess the correlation between clinical events (e.g. rejection, recurrent disease, biliary obstruction), dd-cfDNA levels, gene expression profiling, ability to assess microchimerism, develop predictive analytics, infectious disease diagnoses and finally examine graft histology.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Nucleic acid biomarkers to assess graft injury after liver transplantation.
Bardhi E, McDaniels J, Rousselle T, Maluf DG, et al · · 2022 · cited 15× · PMID 35243279 · DOI 10.1016/j.jhepr.2022.100439
Verify or expand the search:
- PubMed search for NCT04793360
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Liver Transplantation
Currently open trials in the same condition.
- NCT07157631 — Efficacy and Safety of Tranexamic Acid in Adult Liver Transplantation---ESTA Trial · NA · recruiting
- NCT07123740 — Comparison of the Postoperative Analgesic Effects of ITM and Bi-level ESPB in Liver Transplantation Donors · NA · recruiting
- NCT06717919 — HOPE Against Cancer Recurrence in HCC · Phase 4 · recruiting
- NCT06868589 — Reducing Pain With Methadone and Ketamine in Liver Transplant · Phase 4 · active not recruiting
- NCT06874296 — Assessing Declined Liver Grafts With Normothermic Machine Perfusion to Reduce Transplant Waiting Time · NA · recruiting
Other CareDx trials
Trials by the same sponsor.
- NCT05050955 — AlloSure Lung Assessment and Metagenomics Outcomes Study · active not recruiting
- NCT05033548 — Technology Enabled And Molecular Monitoring of the Allograft and Transplant rEcipient · terminated
- NCT04635384 — Assessment of Chimerism and Relapse Post Bone Marrow/Hematopoietic Cell Transplant (HCT) Using AlloHeme Test · active not recruiting
- NCT04601155 — Transition of Renal Patients Using AlloSure Into Community Kidney Care · completed
- NCT04341103 — AlloSure Guided Immuno-Optimization for COVID-19: An Early Experience · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04793360 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by CareDx
- Last refreshed: 23 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04793360.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing