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NCT04792944: BA&UK
Brain Aneurysms: Utility of Cisternal Urokinase Irrigation
trial testing Urokinase in Subarachnoid Hemorrhage, Aneurysmal in 247 participants. Completed in 31 December 2020.
31 December 2020
Quick facts
| Lead sponsor | University of Valencia |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 247 |
| Start date | 1 January 2007 |
| Primary completion | 31 December 2020 |
| Estimated completion | 31 December 2020 |
| Sites | 1 location across Spain |
Drugs / interventions tested
- Urokinase — full drug profile →
- Endovascular treatment
- Clipping
- External ventricular drain
Conditions studied
- Subarachnoid Hemorrhage, Aneurysmal — all drugs for Subarachnoid Hemorrhage, Aneurysmal →
- Vasospasm, Cerebral — all drugs for Vasospasm, Cerebral →
- Hydrocephalus — all drugs for Hydrocephalus →
Sponsor
University of Valencia
Who can join
18 and older, any sex, with Subarachnoid Hemorrhage, Aneurysmal or Vasospasm, Cerebral. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Despite the efforts made in its treatment, aneurysmal subarachnoid haemorrhage continues to induce high mortality and morbidity rates. Today there are treatment protocols in all hospitals. The vast majority prefer, whenever possible, the endovascular route, given its lesser aggressiveness and morbidity. Although embolization prevents aneurysm' rebleeding, it does remove the subarachnoid blood clot. Therefore, it does not modify the evolution, incidence and severity of vasospasm. The idea is to carry out a 10-year retrospective study classifying patients into five groups based on the type of treatment received, analyzing the results' differences. The aim is to improve what is done as much as possible and to be able to propose potential areas for improvement. Besides, this study will be the basis of a future prospective study, prepared without the current one's biases and errors.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Assessment of Safety and Biodistribution of AAVrh.10hCLN2 Following Intracisternal Administration in Nonhuman Primates for the Treatment of CLN2 Batten Disease.
De BP, Rosenberg JB, Selvan N, Wilson I, et al · · 2023 · cited 8× · PMID 37624739 · DOI 10.1089/hum.2023.067 -
Can a single basal cistern urokinase bolus help to prevent subarachnoid hemorrhage consequences?
Vanaclocha V, Herrera JM, Rivera-Paz M, Saiz-Sapena N, et al · · 2024 · PMID 39584093 · DOI 10.1016/j.heliyon.2024.e40080
Verify or expand the search:
- PubMed search for NCT04792944
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Urokinase
Trials testing the same drug.
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- NCT06194968 — Treatment of Acute Ischemic StroKe With Intravenous UroKinase Real-world Research: a Multicenter, Prospective Study · recruiting
- NCT06802679 — Comparison of Standard Versus High Dose Urokinase for Dysfunctional Tunneled Dialysis Catheters in Haemodialysis Patient · Phase 4 · completed
- NCT03997292 — Intravenous Thrombolysis Registry for Acute Ischemic Stroke in China · withdrawn
Other recruiting trials for Subarachnoid Hemorrhage, Aneurysmal
Currently open trials in the same condition.
- NCT04696523 — Effect of Xenon on Brain Injury After Aneurysmal Subarachnoid Hemorrhage · Phase 2 · recruiting
- NCT06819657 — Safety , Feasibility and Preliminary Efficacy of Remote Ischemic Conditioning in Patients With Aneurysmal Subarachnoid H · NA · recruiting
- NCT06766422 — AI Models for Cerebral Aneurysms Segmentation, Detection and Stability Prediction · recruiting
- NCT06906432 — Mechanisms of Brain-Heart Injury of Post-Intracranial Hemorrhage · recruiting
- NCT06218654 — Hemodynamic Instability of Patient With Spontaneous Subarachnoid Hemorrhage · recruiting
Other University of Valencia trials
Trials by the same sponsor.
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- NCT07471555 — Vascular Access and Intraosseus · NA · enrolling by invitation
- NCT07463066 — Long-Term Effectiveness of Pain Neuroscience Education in Women With Genito-Pelvic Pain/Penetration Disorder. · not yet recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04792944 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Valencia
- Last refreshed: 11 March 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04792944.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing