Last reviewed · How we verify
NCT04792697: CARRS-P2
Experimental Manipulation of Sleep and Circadian Rhythms and the Role Played on Reward Function in Teens
NA trial testing Increase morning bright light in Delayed Sleep Phase Syndrome in 100 participants. Currently enrolling.
31 March 2026
Quick facts
| Lead sponsor | University of Pittsburgh |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | basic science |
| Enrollment | 100 |
| Start date | 1 May 2021 |
| Primary completion | 31 March 2026 |
| Estimated completion | 30 June 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Increase morning bright light
- Decrease evening blue light
- Sleep Scheduling
- Monitor sleep, mood, and substance use
Conditions studied
- Delayed Sleep Phase Syndrome — all drugs for Delayed Sleep Phase Syndrome →
Sponsor
University of Pittsburgh
Who can join
Adults 13 to 15, any sex, with Delayed Sleep Phase Syndrome. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Adolescence is a time of heightened reward sensitivity and greater impulsivity. On top of this, many teenagers experience chronic sleep deprivation and misalignment of their circadian rhythms due to biological shifts in their sleep/wake patterns paired with early school start times. Many studies find that this increases the risk for substance use (SU). However, what impact circadian rhythm and sleep disruption either together or independently have on the neuronal circuitry that controls reward and cognition, or if there are interventions that might help to modify these disruptions is unknown. Project 2 (P2) of the CARRS center will test an innovative and mechanistic model of brain circuitry that uses multi-method approaches, takes a developmental perspective, and incorporates key sleep and reward constructs.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT04792697
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Increase morning bright light
Trials testing the same drug.
- NCT03806296 — Delayed Sleep Timing in Teens Study · NA · completed
Other recruiting trials for Delayed Sleep Phase Syndrome
Currently open trials in the same condition.
- NCT06874855 — Lemborexant in Delayed Sleep Phase Syndrome · Phase 4 · recruiting
Other University of Pittsburgh trials
Trials by the same sponsor.
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- NCT06652815 — Cognition, Metacognition, and Stigma in Patients With Suicidal Ideation · not yet recruiting
- NCT06474286 — Prucalopride for Cognitive Functioning in Schizophrenia · NA · not yet recruiting
- NCT06488469 — Behavioural Problems and Cognition in Children With Hypoglycemia Unawareness in Type-1 Diabetes Mellitus · NA · not yet recruiting
- NCT06652802 — Effectiveness of Nurse-Conducted Brief Intervention (NCBI) Supplemented With Mobile for Preventing Alcohol Use Disorders · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04792697 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Pittsburgh
- Last refreshed: 12 November 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04792697.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing