NCT04792437

Research on Precise Immune Prevention and Treatment of Glioma Based on Multi-omics Sequencing Data

Status unknown Last updated 24 March 2021

What this trial tests

trial testing surgery in Transcriptomics in 120 participants. Status unknown.

Timeline

10 March 2021

Primary endpoint
30 September 2022

30 September 2022

Quick facts

Lead sponsor	Yu Yao, MD
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	120
Start date	10 March 2021
Primary completion	30 September 2022
Estimated completion	30 September 2022
Sites	1 location across China

Drugs / interventions tested

• surgery

Conditions studied

• Transcriptomics — all drugs for Transcriptomics →
• Radiomics — all drugs for Radiomics →
• Glioma — all drugs for Glioma →

Sponsor

Yu Yao, MD

Who can join

Adults 18 to 80, any sex, with Transcriptomics or Radiomics. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This project intends to use multiple types of biological samples from glioma patients and mouse intracranial tumor models as research objects, and comprehensively apply a series of omics sequencing technologies and molecular biology technologies to jointly define the following research objectives :

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. Going circular: history, present, and future of circRNAs in cancer.
   Pisignano G, Michael DC, Visal TH, Pirlog R, et al · · 2023 · cited 181× · PMID 37587333 · DOI 10.1038/s41388-023-02780-w
2. T cell exhaustion in malignant gliomas.
   Watowich MB, Gilbert MR, Larion M. · · 2023 · cited 84× · PMID 36681605 · DOI 10.1016/j.trecan.2022.12.008
3. Targeting miRNAs and Other Non-Coding RNAs as a Therapeutic Approach: An Update.
   Bayraktar E, Bayraktar R, Oztatlici H, Lopez-Berestein G, et al · · 2023 · cited 51× · PMID 37104009 · DOI 10.3390/ncrna9020027
4. Emerging roles of circular RNAs in liver cancer.
   Louis C, Leclerc D, Coulouarn C. · · 2022 · cited 25× · PMID 35036887 · DOI 10.1016/j.jhepr.2021.100413
5. The Emerging Value of Circular Noncoding RNA Research in Cancer Diagnosis and Treatment.
   Jagtap U, Anderson ES, Slack FJ. · · 2023 · cited 24× · PMID 36919419 · DOI 10.1158/0008-5472.can-22-3014
6. Translational Bioinformatics Applied to the Study of Complex Diseases.
   Casotti MC, Meira DD, Alves LNR, Bessa BGO, et al · · 2023 · cited 12× · PMID 36833346 · DOI 10.3390/genes14020419
7. Dynamic Intercell Communication between Glioblastoma and Microenvironment through Extracellular Vesicles.
   Krapež G, Kouter K, Jovčevska I, Videtič Paska A. · · 2022 · cited 8× · PMID 35052830 · DOI 10.3390/biomedicines10010151
8. Radiomics-guided checkpoint inhibitor immunotherapy for precision medicine in cancer: A review for clinicians.
   Zhou H, Luo Q, Wu W, Li N, et al · · 2023 · cited 6× · PMID 36936913 · DOI 10.3389/fimmu.2023.1088874