Last reviewed · How we verify
NCT04791995: ReCapp
Resuscitation and Capillary Reperfusion
trial in Cardiac Arrest in 50 participants. Completed in 1 May 2022.
31 March 2022
Quick facts
| Lead sponsor | Medical University of Vienna |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 50 |
| Start date | 3 March 2021 |
| Primary completion | 31 March 2022 |
| Estimated completion | 1 May 2022 |
| Sites | 1 location across Austria |
Conditions studied
- Cardiac Arrest — all drugs for Cardiac Arrest →
- Cardiac Arrest, Out-Of-Hospital — all drugs for Cardiac Arrest, Out-Of-Hospital →
- Cardiopulmonary Arrest — all drugs for Cardiopulmonary Arrest →
- Cardiopulmonary Arrest With Successful Resuscitation — all drugs for Cardiopulmonary Arrest With Successful Resuscitation →
Sponsor
Medical University of Vienna
Who can join
Adults 18 to 95, any sex, with Cardiac Arrest or Cardiac Arrest, Out-Of-Hospital. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Persistent microperfusion alterations after return of spontaneous circulation (ROSC) are associated with poor survival. To our knowledge, no human studies evaluating microperfusion during cardiopulmonary resuscitation (CPR) with simple and pre-hospital available tests have been published. Capillary refill time (CRT) and skin-mottling-score (SMS) are parameters for microperfusion and evaluated in septic and cardiogenic shock. In animal studies, microperfusion was impaired during cardiac arrest, although not correlating with systemic blood pressure. The aim of this study is to investigate the correlation between impaired microcirculation (as measured with CRT and SMS) during resuscitation and ROSC resp. neurological outcome. Our clinical impression in daily routine is, that the appearance of a patient undergoing CPR is often linked to the outcome. We hypothesize, that this is due to changes in microperfusion of the skin.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
The association of capillary refill time and return of spontaneous circulation during out-of-hospital cardiac arrest: an observational study.
Mueller M, Holzer M, Losert H, Grassmann D, et al · · 2025 · PMID 39838473 · DOI 10.1186/s13054-025-05255-4
Verify or expand the search:
- PubMed search for NCT04791995
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04791995 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Medical University of Vienna
- Last refreshed: 26 September 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04791995.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing