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NCT04791787
Effect of Ketogenic Diet on Glucose Metabolism and Energy Expenditure in Type 2 Diabetes
NA trial testing Standard weight maintaining diet in Glucose Metabolism Disorders (Including Diabetes Mellitus) in 35 participants. Completed in 25 April 2023.
25 April 2023
Quick facts
| Lead sponsor | The University of Texas Health Science Center at San Antonio |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | other |
| Enrollment | 35 |
| Start date | 25 November 2020 |
| Primary completion | 25 April 2023 |
| Estimated completion | 25 April 2023 |
| Sites | 2 locations across United States |
Drugs / interventions tested
- Standard weight maintaining diet
- Weight maintaining isocaloric ketogenic diet
- Beta-hydroxy butyrate
Conditions studied
- Glucose Metabolism Disorders (Including Diabetes Mellitus) — all drugs for Glucose Metabolism Disorders (Including Diabetes Mellitus) →
- Energy Supply; Deficiency — all drugs for Energy Supply; Deficiency →
- Type 2 Diabetes — all drugs for Type 2 Diabetes →
Sponsor
The University of Texas Health Science Center at San Antonio
Who can join
Adults 18 to 70, any sex, with Glucose Metabolism Disorders (Including Diabetes Mellitus) or Energy Supply; Deficiency. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The study team will examine the effect of a ketogenic diet alone and ketogenic diet supplemented with oral ketones on how the body of individuals with type 2 diabetes respond to insulin, regulates insulin secretion, food intake and energetic pathways and influences body fat distribution.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
The Role of the Gut Microbiota on the Beneficial Effects of Ketogenic Diets.
Attaye I, van Oppenraaij S, Warmbrunn MV, Nieuwdorp M. · · 2021 · cited 52× · PMID 35011071 · DOI 10.3390/nu14010191 -
Ketone body metabolism and cardiometabolic implications for cognitive health.
Fulghum K, Salathe SF, Davis X, Thyfault JP, et al · · 2024 · cited 11× · PMID 40093558 · DOI 10.1038/s44324-024-00029-y
Verify or expand the search:
- PubMed search for NCT04791787
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Glucose Metabolism Disorders (Including Diabetes Mellitus)
Currently open trials in the same condition.
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- NCT07172009 — The Effect of Chlorhexidine Mouthwash on Postprandial Glucose Response in Healthy Individuals · NA · recruiting
Other The University of Texas Health Science Center at San Antonio trials
Trials by the same sponsor.
- NCT07280897 — SCIPI Implementation and Evaluation: A Multi-site Proof-of-Concept Pilot Trial · NA · not yet recruiting
- NCT07053319 — SGLT2i, Pioglitazone, and Ketone Production in T2D · Phase 1 · recruiting
- NCT07056699 — SGLT2i, Pioglitazone, and Ketone Production in T1D · Phase 3 · not yet recruiting
- NCT06609343 — Bupropion for Fatigue in End-stage Kidney Disease Patients on Hemodialysis · Phase 1, PHASE2 · not yet recruiting
- NCT07437053 — Sarcopenia in Chronic Kidney Disease (CKD) Patients · EARLY_PHASE1 · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04791787 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by The University of Texas Health Science Center at San Antonio
- Last refreshed: 11 June 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04791787.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing