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Protein-bound Versus Free Amino Acid Nutrition During INtestinal Malabsorption in Critical Illness (PANINI)
In the current study, we willquantitate the difference in digestion and absorption kinetics of dietary whole protein versus free amino acids in vivo in critically ill patients admitted to the intensive care unit suffering from malabsorption. 16 adult, mechanically ventilated ICU patients with clinical signs of malabsorption (faecal weight \>350 g/day) will be included. All patients will receive a primed continuous intravenous infusion of L-\[ring2H5\]-phenylalanine and L-\[3,5-2H2\]-Tyrosine for the duration of the study period. After reaching an isotopic steady state (1.5 hours), patients will receive either \[1-13C\]- phenylalanine labelled milk protein or free amino acids with an identical constitution and \[1-13C\]-phenylalanine. Main study endpoint will be the splanchnic extraction of phenylalanine, calculated from systemic \[1-13C\]- and L-\[ring2H5\]-phenylalanine enrichment.
Details
| Lead sponsor | Maastricht University Medical Center |
|---|---|
| Phase | NA |
| Status | COMPLETED |
| Enrolment | 16 |
| Start date | Tue Mar 27 2018 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Sat Nov 30 2019 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Intestinal Malabsorption
- Critical Illness
- Protein Malnutrition
Interventions
- Milk protein (food grade protein)
- Fee amino acids (food grade amino acids)
Countries
Netherlands