NCT04788927 (PPGL-Pred) is a clinical trial in Paraganglioma, sponsored by Rigshospitalet, Denmark.

Who is sponsoring NCT04788927?

NCT04788927 is sponsored by Rigshospitalet, Denmark.

What condition does NCT04788927 study?

NCT04788927 studies Paraganglioma, Pheochromocytoma, Genetic Predisposition to Disease, Pathology, Somatic Mutation, Head and Neck Cancer, Neuroendocrine Tumors.

Is NCT04788927 still recruiting?

NCT04788927 is currently not yet recruiting. Last updated 7 April 2023.

Last reviewed 2023-04-07 · How we verify

NCT04788927: PPGL-Pred

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Development of a Predictive Model for the Risk of Metastatic Disease in PPGLs, a Retrospective Cohort Study

Not yet recruiting Last updated 7 April 2023

What this trial tests

trial in Paraganglioma in 400 participants. Not yet recruiting.

Timeline

1 October 2023

Primary endpoint
30 April 2024

30 September 2027

Quick facts

Lead sponsor	Rigshospitalet, Denmark
Status	Not yet recruiting
Study type	OBSERVATIONAL
Enrollment	400
Start date	1 October 2023
Primary completion	30 April 2024
Estimated completion	30 September 2027
Sites	2 locations across Denmark

Conditions studied

Paraganglioma — all drugs for Paraganglioma →
Pheochromocytoma — all drugs for Pheochromocytoma →
Genetic Predisposition to Disease — all drugs for Genetic Predisposition to Disease →
Pathology — all drugs for Pathology →

Sponsor

Rigshospitalet, Denmark

Who can join

Adults 0 to 120, any sex, with Paraganglioma or Pheochromocytoma. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Phaeochromocytomas and paragangliomas (PPGLs) are tumours of the adrenal medulla and extra-adrenal sympathetic nervous system, some which can become metastatic. It is a very rare disease and the tumours are often detected late. Approximately 50 % of the tumours are caused by germline genetic variants screening programmes are recommended for patients and their family members; however, they are not yet well-targeted with respect to individual prognosis. In this study the investigatorscaim to characterize the genotype-phenotype associations in all Danish patients (n=400) diagnosed with PPGLs who have been followed in tertiary centres using medical records and national registries. To this end novel immunohistochemical, genetic, and epigenetic biomarkers in tumour tissues samples from biobank material (blood samples and tumour tissue) will be investigated to develop a comprehensive predictive algorithm for disease prognosis. The study will provide a clinical tool for an improved targeted screening program and subsequently prevention of disease development.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other recruiting trials for Paraganglioma

Currently open trials in the same condition.

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NCT06377033 — Using the EHR to Advance Genomic Medicine Across a Diverse Health System · NA · recruiting
NCT06444607 — Hereditary Pheochromocytoma Assessment of Tumour Immunologies · recruiting
NCT06440122 — The Incidence and Outcomes of Metabolically Active Brown Adipose Tissue (aBAT) in Patients With Pheochromocytoma or Para · recruiting

Other Rigshospitalet, Denmark trials

Trials by the same sponsor.

NCT07401368 — Clinicians' Trust in AI-Based Fetal Growth Estimates · NA · not yet recruiting
NCT07442357 — The Per-procedural Antibiotic Prophylaxis in Patients Undergoing Transcatheter Aortic Valve Implantation Trial · NA · not yet recruiting
NCT07528729 — Alcohol as a Modifiable Risk Factor for Atrial Fibrillation · NA · not yet recruiting
NCT07511439 — Reversible Effects of Oral Contraceptive Removal on Serotonergic Neurotransmission · Phase 4 · not yet recruiting
NCT07467187 — Invasive Home Ventilation in Denmark · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04788927 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Rigshospitalet, Denmark
Last refreshed: 7 April 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04788927.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing