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NCT04782765

Phase Ⅱ Trial of Camrelizumab in Patients Without Distant Metastasis Nasopharyngeal Carcinoma

Status unknown Phase 2 Last updated 4 March 2021
What this trial tests

Phase 2 trial testing Camrelizumab+Chemotherapy+Chemoradiotherapy in Disease-free Survival Rate in 59 participants. Status unknown.

Timeline
20 March 2021
Primary endpoint
20 March 2023
20 March 2025

Quick facts

Lead sponsorTianjin Medical University Cancer Institute and Hospital
PhasePhase 2
StatusStatus unknown
Study typeINTERVENTIONAL
Allocationna
Designsingle group
Maskingnone
Primary purposetreatment
Enrollment59
Start date20 March 2021
Primary completion20 March 2023
Estimated completion20 March 2025
Sites1 location across China

Drugs / interventions tested

Conditions studied

Sponsor

Tianjin Medical University Cancer Institute and Hospital

Who can join

Under 70, any sex, with Disease-free Survival Rate. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

To see the effect if a combination of neoadjuvant chemotherapy combined with Camrelizumab followed by chemoradiotherapy in treating patients without distant metastasis nasopharyngeal carcinoma

Publications & conference data

6 peer-reviewed publications reference this trial (live from Europe PMC):

  1. Nasopharyngeal carcinoma: current views on the tumor microenvironment's impact on drug resistance and clinical outcomes.
    Liu H, Tang L, Li Y, Xie W, et al · · 2024 · cited 85× · PMID 38254110 · DOI 10.1186/s12943-023-01928-2
  2. Current status and advances of immunotherapy in nasopharyngeal carcinoma.
    Xu JY, Wei XL, Wang YQ, Wang FH. · · 2022 · cited 62× · PMID 35547095 · DOI 10.1177/17588359221096214
  3. Precision medicine in nasopharyngeal carcinoma: comprehensive review of past, present, and future prospect.
    Siak PY, Heng WS, Teoh SSH, Lwin YY, et al · · 2023 · cited 33× · PMID 37932756 · DOI 10.1186/s12967-023-04673-8
  4. Advance in integrating platinum-based chemotherapy with radiotherapy for locally advanced nasopharyngeal carcinoma.
    Zhu F, Wu Y, Wang H. · · 2023 · cited 9× · PMID 37860184 · DOI 10.3389/fonc.2023.1259331
  5. Induction chemotherapy plus camrelizumab combined with concurrent chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma in non-endemic areas: a phase 2 clinical trial in North China.
    Wang Z, Sun Y, Wang Q, Chai Y, et al · · 2025 · cited 5× · PMID 40016735 · DOI 10.1186/s12916-025-03964-9
  6. A Systematic Review and Meta-Analysis of Studies Comparing Concurrent Chemoradiotherapy With Radiotherapy Alone in the Treatment of Stage II Nasopharyngeal Carcinoma.
    Xu YC, Chen KH, Liang ZG, Zhu XD. · · 2022 · cited 2× · PMID 35903695 · DOI 10.3389/fonc.2022.843675

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