Who is sponsoring NCT04781127?

NCT04781127 is sponsored by Soterix Medical.

What drugs are being tested in NCT04781127?

Interventions in NCT04781127: Soterix Medical mini-CT tDCS stimulator.

What condition does NCT04781127 study?

NCT04781127 studies Unipolar Depression, Treatment Resistant Depression.

Is NCT04781127 still recruiting?

NCT04781127 is currently completed. Last updated 30 January 2023.

Last reviewed 2023-01-30 · How we verify

NCT04781127

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Home-administered tDCS for Treatment of Depression

Completed Phase 1 Last updated 30 January 2023

What this trial tests

Phase 1 trial testing Soterix Medical mini-CT tDCS stimulator in Unipolar Depression in 50 participants. Completed in 10 August 2022.

Timeline

10 February 2021

Primary endpoint
10 August 2022

10 August 2022

Quick facts

Lead sponsor	Soterix Medical
Phase	Phase 1
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	50
Start date	10 February 2021
Primary completion	10 August 2022
Estimated completion	10 August 2022
Sites	1 location across United States

Drugs / interventions tested

Soterix Medical mini-CT tDCS stimulator

Conditions studied

Unipolar Depression — all drugs for Unipolar Depression →
Treatment Resistant Depression — all drugs for Treatment Resistant Depression →

Sponsor

Soterix Medical — full company profile →

Who can join

18 and older, any sex, with Unipolar Depression or Treatment Resistant Depression. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study will determine the safety and efficacy of home administered tDCS in adults with unipolar depression. The device used to administer tDCS will be the Soterix Medical 1X1 mini-CT. 32 tDCS sessions of 30 minutes each will be delivered over 10 weeks.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Home-administered transcranial direct current stimulation is a feasible intervention for depression: an observational cohort study.
Charvet L, George A, Charlson E, Lustberg M, et al · · 2023 · cited 14× · PMID 37674552 · DOI 10.3389/fpsyt.2023.1199773
Neuromodulation Strategies to Reduce Inflammation and Improve Lung Complications in COVID-19 Patients.
Czura CJ, Bikson M, Charvet L, Chen JDZ, et al · · 2022 · cited 13× · PMID 35911909 · DOI 10.3389/fneur.2022.897124

Verify or expand the search:

Other trials of Soterix Medical mini-CT tDCS stimulator

Trials testing the same drug.

NCT03833583 — TDCS for Cocaine Addiction Craving · NA · completed

Other recruiting trials for Unipolar Depression

Currently open trials in the same condition.

NCT07216404 — Psilocybin-Assisted Therapy for the Treatment of Major Depressive Disorder in Patients With Non-Small Cell Lung Cancer · Phase 2 · recruiting
NCT07266545 — RNA Editing as a Biomarker of Antidepressant Response in Unipolar and Bipolar Depression (EDIT-ANDRE) · Phase 4 · recruiting
NCT06860165 — Validation of EmoDTx as a Digital Endpoint for Mood Monitoring in Adult Patients Suffering From Unipolar Depression · recruiting
NCT07042217 — Transcranial Direct Current Stimulation for Depression · NA · recruiting
NCT06472492 — Cognitive Enhancement in Unipolar Depression With Yoga · NA · recruiting

Other Soterix Medical trials

Trials by the same sponsor.

NCT07307768 — Ketamine Biomarker Validation · Phase 1 · not yet recruiting
NCT07287839 — Parcel-guided rTMS for Major Depressive Disorder · Phase 2 · not yet recruiting
NCT07042217 — Transcranial Direct Current Stimulation for Depression · NA · recruiting
NCT04956081 — Virtual Neuro-Navigation System for Personalized Community Based TMS · NA · completed
NCT05598931 — Development of Neuro-Navigated Transcranial Magnetic Stimulation (TMS) Using MRI · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04781127 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Soterix Medical
Last refreshed: 30 January 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04781127.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing