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Observation and Treatment of Pulmonary Microthrombosis in Childhood Pneumonia With Elevated D-dimer
Objective 1\. Master the clinical feathers, imaging features and laboratory diagnosis characteristics and economic costs of children pneumonia with higher D-dimer: 1. Compare the characteristics of different groups of children in the course of the disease，clinicalsymptoms and signs; 2. All the children in the study need to do enhanced CT, to observe if there were intrapulmonary vascular thrombosis and necrosis pneumonia signs; 3. compared changes of coagulation index beside D-dimer. 2\. Compared with low molecular weight heparin prevention Disseminated intravascular coagulation（DIC） dose and instructions to the recommended dose in safety and effectiveness,and proposed elevated anticoagulation D-Dimer specification of the clinical treatment of children with pneumonia. Background and rationale: Pneumonia is the main cause of lung function injury and death in children. The high blood coagulation state can lead to the formation of pulmonary vascular thrombosis, local pulmonary ischemia and necrosis, which may be an important mechanism for the occurrence of necrotizing pneumonia and pulmonary embolism in children with pneumonia. Elevated D-dimer is an important predictor of pulmonary thrombosis and necrotizing pneumonia. At present, D-Dimer in many children with severe pneumonia is found to increase, the symptom is severe, the late stage of the performance of necrotizing pneumonia, seriously affect the children's lung function and quality of life.
Details
| Lead sponsor | Capital Institute of Pediatrics, China |
|---|---|
| Phase | Phase 4 |
| Status | COMPLETED |
| Enrolment | 124 |
| Start date | 2014-12 |
| Completion | 2018-02 |
Conditions
- Pneumonia
Interventions
- Low-Molecular-Weight Heparins Calcium Injection
Primary outcomes
- Lung imaging absorption improvement time after treatment — Change from basline in lung imaging at 1 month
The enrolled children were subjected to weekly imaging examinations to determine the time for the absorption of lung inflammation to improve.Criteria for evaluating the severity of CT changes (large lung shadows or dot shadows in CT images) : Criteria for improvement of lung imaging absorption: no obvious lesion absorption, no absorption or large patchy shadow; Partial absorption of lesions: there is absorption, but there is still patchy shadow or cloud flocculent shadow; Obvious absorption of lesions: no abnormalities or only a little light in the lung. - Time to improve cough symptoms — 2 weeks
The clinician will judge the improvement time of the child's cough symptoms - Heat retreat time — 2 weeks
The time required for temperature to drop below 37.3℃ after treatment. - The time to disappear rhonchus in the lungs — 2 weeks
The clinician will judge the absorption time of dry and wet rhonchus in the lungs.
Countries
China