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NCT04778839
Study of Paclitaxel Micelles for Injection in Chinese Patients With Advanced Solid Tumors.
Phase 1 trial testing Paclitaxel Micelles for Injection in Advanced Solid Tumors in 98 participants. Currently enrolling.
30 June 2026
Quick facts
| Lead sponsor | First Affiliated Hospital of Zhejiang University |
|---|---|
| Phase | Phase 1 |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 98 |
| Start date | 4 March 2021 |
| Primary completion | 30 June 2026 |
| Estimated completion | 30 June 2026 |
| Sites | 1 location across China |
Drugs / interventions tested
- Paclitaxel Micelles for Injection — full drug profile →
- Paclitaxel injection — full drug profile →
Conditions studied
- Advanced Solid Tumors — all drugs for Advanced Solid Tumors →
Sponsor
First Affiliated Hospital of Zhejiang University
Who can join
Adults 18 to 70, any sex, with Advanced Solid Tumors. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
A Phase I Study of Dose Escalation and Dose Expansion To Evaluate the Safety、Tolerability、Pharmacokinetics and Preliminary Efficacy of Paclitaxel Micelles for Injection in Chinese Patients With Advanced Solid Tumor.
Publications & conference data
8 peer-reviewed publications reference this trial (live from Europe PMC):
-
Polymeric Micellar Systems-A Special Emphasis on "Smart" Drug Delivery.
Negut I, Bita B. · · 2023 · cited 66× · PMID 36986837 · DOI 10.3390/pharmaceutics15030976 -
Exploring the Application of Micellar Drug Delivery Systems in Cancer Nanomedicine.
Wang Q, Atluri K, Tiwari AK, Babu RJ. · · 2023 · cited 42× · PMID 36986532 · DOI 10.3390/ph16030433 -
Nanostructures for drug delivery in respiratory diseases therapeutics: Revision of current trends and its comparative analysis.
Ibarra-Sánchez LÁ, Gámez-Méndez A, Martínez-Ruiz M, Nájera-Martínez EF, et al · · 2022 · cited 19× · PMID 35280919 · DOI 10.1016/j.jddst.2022.103219 -
Advances in Polymeric Micelles: Responsive and Targeting Approaches for Cancer Immunotherapy in the Tumor Microenvironment.
Cheng L, Yu J, Hao T, Wang W, et al · · 2023 · cited 12× · PMID 38004600 · DOI 10.3390/pharmaceutics15112622 -
Functionalized Polymeric Micelles for Targeted Cancer Therapy: Steps from Conceptualization to Clinical Trials.
Serras A, Faustino C, Pinheiro L. · · 2024 · cited 4× · PMID 39204392 · DOI 10.3390/pharmaceutics16081047 -
Recent advances in cancer nanomedicine: From smart targeting to personalized therapeutics - pioneering a new era in precision oncology.
Younas A, Wang S, Asad M, Al Mamun A, et al · · 2026 · cited 3× · PMID 41560793 · DOI 10.1016/j.mtbio.2025.102660 -
Advances in Polymer Micelles for Cancer Therapy: From Conventional to Smart Delivery Systems
Bryaskova R, Staykov K, Ganchev D. · · 2026 -
Recent Advances in the Applications of Biomaterials in Ovarian Cancer.
Mahfuz AMUB, Janorkar AV, Rocconi RP, Duan Y. · · 2025 · PMID 41294440 · DOI 10.3390/biomimetics10110768
Verify or expand the search:
- PubMed search for NCT04778839
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Advanced Solid Tumors
Currently open trials in the same condition.
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- NCT07589530 — Phase 1/2 Study of EB-NK-301 (Allogeneic TROP2-CAR NK Cells) in Advanced TROP2-Expressing Solid Tumors · Phase 1, PHASE2 · recruiting
- NCT07360314 — Anti-Ly6E Exatecan ADC M7437 in Advanced Solid Tumors · Phase 1 · recruiting
- NCT07414316 — A Single-Arm, Open-Label Clinical Study GK01 Cell Injection in Subjects With Advanced Solid Tumors. · EARLY_PHASE1 · recruiting
- NCT07222969 — A Clinical Study to Evaluate the Safety of VIB305 in Patients With Advanced Solid Tumors · Phase 1, PHASE2 · recruiting
Other First Affiliated Hospital of Zhejiang University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04778839 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by First Affiliated Hospital of Zhejiang University
- Last refreshed: 6 August 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04778839.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing