Who is sponsoring NCT04775394?

NCT04775394 is sponsored by Prof. Dr. Jens Hohlfeld.

What drugs are being tested in NCT04775394?

Interventions in NCT04775394: Bronchoscopy.

What condition does NCT04775394 study?

NCT04775394 studies Chronic Obstructive Pulmonary Disease.

Is NCT04775394 still recruiting?

NCT04775394 is currently completed. Last updated 1 August 2023.

Last reviewed 2023-08-01 · How we verify

NCT04775394

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Activation of Apoptosis-related Receptors on Alveolar Macrophages

Completed NA Last updated 1 August 2023

What this trial tests

NA trial testing Bronchoscopy in Chronic Obstructive Pulmonary Disease in 28 participants. Completed in 21 July 2023.

Timeline

1 January 2021

Primary endpoint
21 July 2023

21 July 2023

Quick facts

Lead sponsor	Prof. Dr. Jens Hohlfeld
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	sequential
Masking	none
Primary purpose	basic science
Enrollment	28
Start date	1 January 2021
Primary completion	21 July 2023
Estimated completion	21 July 2023
Sites	1 location across Germany

Drugs / interventions tested

Bronchoscopy

Conditions studied

Chronic Obstructive Pulmonary Disease — all drugs for Chronic Obstructive Pulmonary Disease →

Sponsor

Prof. Dr. Jens Hohlfeld

Who can join

Adults 40 to 80, any sex, with Chronic Obstructive Pulmonary Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The aim is to understand whether activation of receptors involved in clearance of apoptotic cells will improve efferocytosis in COPD patients in vitro and whether generation of pro-inflammatory cytokines can be decreased in COPD patients.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Alveolar macrophages in tissue homeostasis, inflammation, and infection: evolving concepts of therapeutic targeting.
Malainou C, Abdin SM, Lachmann N, Matt U, et al · · 2023 · cited 107× · PMID 37781922 · DOI 10.1172/jci170501
Efferocytosis of vascular cells in cardiovascular disease.
Cabrera JTO, Makino A. · · 2022 · cited 24× · PMID 34171333 · DOI 10.1016/j.pharmthera.2021.107919

Verify or expand the search:

Other trials of Bronchoscopy

Trials testing the same drug.

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NCT07380373 — Comparative Analysis of Salivary and Bronchoalveolar Lavage IL-6 and TNF-α as Biomarkers in Pediatric Acute Respiratory · enrolling by invitation
NCT06935695 — Surveillance Versus Bronchoscopy After Airway Stenting · NA · recruiting
NCT06600646 — Investigating the Role of ATP Production by Airway Epithelium in Patients With Refractory and Unexplained Chronic Cough · recruiting
NCT06105801 — EBUS-TBNA vs Transbronchial Mediastinal Cryobiopsy for Adequacy of Next Generation Sequencing · Phase 4 · recruiting

Other recruiting trials for Chronic Obstructive Pulmonary Disease

Currently open trials in the same condition.

NCT06749262 — Inclined Versus Standard Exercise for COPD Patients · NA · recruiting
NCT07406659 — Different Inspiratory Muscle Trainings in Patients With COPD · NA · recruiting
NCT07051707 — Evaluating the Safety and Efficacy of dNerva Lung Denervation System in Patients With COPD · NA · recruiting
NCT07418736 — A Phase II Study of CM326 in Subjects With Moderate to Severe Chronic Obstructive Pulmonary Disease · Phase 2 · recruiting
NCT07069829 — Study of Clinical and Patient-reported Outcomes in Adults With Moderate to Severe COPD Treated With Breztri/Trixeo · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04775394 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Prof. Dr. Jens Hohlfeld
Last refreshed: 1 August 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04775394.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing