Last reviewed · How we verify
NCT04775147
Intensive Control of Blood Pressure in Acute Ischemic Stroke After Endovascular Therapy on Clinical Outcome (CRISIS I)
NA trial testing Intensive BP lowering in Acute Ischemic Stroke in 205 participants. Terminated before completion.
3 January 2023
Quick facts
| Lead sponsor | Nanjing First Hospital, Nanjing Medical University |
|---|---|
| Phase | NA |
| Status | Terminated |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 205 |
| Start date | 3 July 2020 |
| Primary completion | 3 January 2023 |
| Estimated completion | 3 January 2023 |
| Sites | 1 location across China |
Drugs / interventions tested
- Intensive BP lowering
Conditions studied
- Acute Ischemic Stroke — all drugs for Acute Ischemic Stroke →
Sponsor
Nanjing First Hospital, Nanjing Medical University
Who can join
18 and older, any sex, with Acute Ischemic Stroke. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
CRISIS I is a prospective, multicenter, randomized controlled trial, to asses the impact of intensive blood pressure control on clinical outcome of acute ischemic stroke patients with successful recanalization after endovascular therapy.
Publications & conference data
7 peer-reviewed publications reference this trial (live from Europe PMC):
-
Intensive vs Conventional Blood Pressure Lowering After Endovascular Thrombectomy in Acute Ischemic Stroke: The OPTIMAL-BP Randomized Clinical Trial.
Nam HS, Kim YD, Heo J, Lee H, et al · · 2023 · cited 120× · PMID 37668619 · DOI 10.1001/jama.2023.14590 -
Integrated care for optimizing the management of stroke and associated heart disease: a position paper of the European Society of Cardiology Council on Stroke.
Lip GYH, Lane DA, Lenarczyk R, Boriani G, et al · · 2022 · cited 102× · PMID 35552401 · DOI 10.1093/eurheartj/ehac245 -
Blood Pressure Management After Endovascular Thrombectomy.
Peng TJ, Ortega-Gutiérrez S, de Havenon A, Petersen NH. · · 2021 · cited 20× · PMID 34539562 · DOI 10.3389/fneur.2021.723461 -
Blood pressure management after endovascular thrombectomy: Insights of recent randomized controlled trials.
Dong X, Liu Y, Chu X, Yu E, et al · · 2024 · cited 2× · PMID 39118229 · DOI 10.1111/cns.14907 -
2023 Neurocritical Care Updates in Cerebrovascular Disease.
Jha RM, Sheth KN. · · 2023 · cited 2× · PMID 37747966 · DOI 10.1161/strokeaha.123.043018 -
Pretreatment collateral circulation status modifies the effect of blood pressure trajectory on outcome after endovascular therapy
Li Z, Ji L, Zhang L, Zhang S, et al · · 2025 · DOI 10.21203/rs.3.rs-7331436/v1 -
Exploring the impact of intensive versus standard blood pressure management following post-endovascular therapy in ischemic stroke: A comparative systematic review and meta-analysis.
Kumar Karmani V, Mashkoor Y, Riaz A, Khalid Z, et al · · 2025 · PMID 40432989 · DOI 10.5339/qmj.2025.21
Verify or expand the search:
- PubMed search for NCT04775147
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Intensive BP lowering
Trials testing the same drug.
- NCT04140110 — Second Enhanced Control of Hypertension and Thrombectomy Stroke Study (ENCHANTED2) · NA · terminated
Other recruiting trials for Acute Ischemic Stroke
Currently open trials in the same condition.
- NCT07115940 — Medical Management With Endovascular Thrombectomy Versus Medical Management Alone in Patients Presenting Beyond 24 Hours · NA · recruiting
- NCT07404852 — Non-invasive Vagus Nerve Stimulation to Reduce Inflammation and Brain Injury Blood Biomarkers Following an Acute Ischemi · NA · recruiting
- NCT07361302 — A Study to Test if Tenecteplase Helps People to Recover From an Acute Stroke When Given More Than 4.5 Hours After the Pe · Phase 3 · recruiting
- NCT07436156 — SUMMIT RISE Study of Acute Ischemic Stroke Patients · Phase 4 · recruiting
- NCT07203625 — Tenecteplase Before Interhospital Transfer in Acute Basilar Artery Occlusion at 4.5 to 24 Hours · Phase 4 · recruiting
Other Nanjing First Hospital, Nanjing Medical University trials
Trials by the same sponsor.
- NCT07349979 — PCI With Guideline-Directed Medical Therapy for HFpEF Patients With Ischemic Cardiomyopathy · NA · not yet recruiting
- NCT07505056 — Jianpi Lishi Jiedu Granules for Prevention of Postoperative Recurrence in Colorectal Advanced Adenomas · Phase 3 · not yet recruiting
- NCT07397234 — Thyroid Cartilage Plane VS Superior Laryngeal Nerve Space Block in Awake Tracheal Intubation · NA · not yet recruiting
- NCT07455448 — Antibiotic Resistance of Helicobacter Pylori in Nanjing: A Cross-Sectional Study · completed
- NCT07385885 — Ultrasound-guided Non-invasive Simulation in Anesthesia Residency Training · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04775147 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Nanjing First Hospital, Nanjing Medical University
- Last refreshed: 24 July 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04775147.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing