Last reviewed · How we verify
NCT04773899: CAUSED
COVID-19 Associated Endothelial Dysfunction Study
NA trial testing Procedure : Multimodal microvascular assessment at study inclusion in Covid19 in 75 participants. Completed in 21 December 2022.
21 October 2022
Quick facts
| Lead sponsor | University Hospital, Angers |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 75 |
| Start date | 22 October 2021 |
| Primary completion | 21 October 2022 |
| Estimated completion | 21 December 2022 |
| Sites | 2 locations across France |
Drugs / interventions tested
- Procedure : Multimodal microvascular assessment at study inclusion
Conditions studied
- Covid19 — all drugs for Covid19 →
- Microcirculation — all drugs for Microcirculation →
Sponsor
University Hospital, Angers
Who can join
18 and older, any sex, with Covid19 or Microcirculation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
SARS-CoV-2 enters human cells through the binding of the spike protein with angiotensin converting enzyme-2 (ACE2), a membrane receptor highly expressed in immune or non-immune cells, and in many organs, including lungs and endothelial cells. In COVID-19 disease, the infection of endothelial might cause an acute endothelial dysfunction. The objective of this study is to demonstrate that patients COVID19 (+) hospitalized in ICU present an acute endothelial dysfunction (compared with COVID19 (-) also hospitalized in ICU). This acute endothelial dysfunction could lead to organ failure, systemic immune dysregulation and thrombosis.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
DETECTION AND QUANTIFICATION OF MICROCIRCULATORY DYSFUNCTION IN SEVERE COVID-19 NOT REQUIRING MECHANICAL VENTILATION: A THREE-ARM COHORT STUDY.
Abrard S, Coquet T, Riou J, Rineau E, et al · · 2024 · cited 2× · PMID 39158987 · DOI 10.1097/shk.0000000000002451
Verify or expand the search:
- PubMed search for NCT04773899
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other University Hospital, Angers trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04773899 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital, Angers
- Last refreshed: 6 May 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04773899.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing