NCT04771637

Effect of Dexmedetomidine on Perioperative Internal Environment and Rehabilitation of Patients Undergoing Gastrointestinal Malignant Tumor Resection

Completed NA Last updated 30 November 2021

What this trial tests

NA trial testing Dexmedetomidine in Dexmedetomidine in 140 participants. Completed in 30 August 2020.

Timeline

1 January 2017

Primary endpoint
30 August 2020

30 August 2020

Quick facts

Lead sponsor	Yangzhou University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	140
Start date	1 January 2017
Primary completion	30 August 2020
Estimated completion	30 August 2020
Sites	1 location across China

Drugs / interventions tested

• Dexmedetomidine (dexmedetomidine) — full drug profile →
• Dexmedetomidine (dexmedetomidine) — full drug profile →
• Dexmedetomidine (dexmedetomidine) — full drug profile →
• Normal saline

Conditions studied

• Dexmedetomidine — all drugs for Dexmedetomidine →
• Perioperative — all drugs for Perioperative →
• Electrolyte — all drugs for Electrolyte →

Sponsor

Yangzhou University

Who can join

Adults 18 to 65, any sex, with Dexmedetomidine or Perioperative. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Dexmedetomidine is a highly selective alpha2-adrenergic receptor agonist with sedative, analgesic, anti-anxiety, and inhibitory sympathetic nerve excitation properties. It is commonly used in clinical anesthesia and intensive care.Radical gastrectomy for gastrointestinal malignant tumors is a common major operation in clinical practice, with long operation time, great trauma and strong stress response of patients. Dexmedetomidine is often used in general anesthesia during such operations, but its long-term use or large dose may produce certain side effects.Common side effects of dexmedetomidine include bradycardia and hypotension, etc. Previous studies have reported that dexmedetomidine can prolong QT interval and is at risk of causing tip torsion type ventricular tachycardia.Abnormal Potassium may affect myocardial repolarization and increase the risk of tip torsion ventricular tachycardia.The main purpose of this study was to observe the effects of long-term use of dexmedetomidine on perioperative internal environment such as electrolyte and rehabilitation indicators during radical general anesthesia for gastrointestinal malignancy, and the secondary purpose was to explore the optimal dose of dexmedetomidine for general anesthesia for patients undergoing radical general anesthesia for gastrointestinal malignancy.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Effects of Dexmedetomidine on Perioperative Serum Potassium and Postoperative Rehabilitation of Patients Undergoing Radical Resection of Gastrointestinal Malignancy
   Tian S, Zhang D, Wang Y, Yu L, et al · · 2021 · DOI 10.21203/rs.3.rs-1169113/v1