Last reviewed · How we verify
NCT04770116
Auditory Slow Wave Enhancement After Concussion
NA trial testing Auditory Stimulation in Concussion Post Syndrome in 120 participants. Currently enrolling.
31 March 2026
Quick facts
| Lead sponsor | University Children's Hospital, Zurich |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 120 |
| Start date | 31 May 2021 |
| Primary completion | 31 March 2026 |
| Estimated completion | 31 March 2026 |
| Sites | 1 location across Switzerland |
Drugs / interventions tested
- Auditory Stimulation
Conditions studied
- Concussion Post Syndrome — all drugs for Concussion Post Syndrome →
Sponsor
University Children's Hospital, Zurich
Who can join
Adults 6 to 18, any sex, with Concussion Post Syndrome. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The prevalence of a traumatic brain injury (TBI) in children and adolescents is around 30% with 70-90% being classified as mild (concussion). Because the brain of a child is still developing, a TBI can have devastating effects and possibly creates lifetime challenges. Sleep seems to play an important role in the post-concussion recovery process. Auditory stimulation during sleep has been shown to reliably boost slow waves, a solid marker for the depth of sleep, and can thus be used to deepen sleep. This study aims to investigate the effects of sleep enhancement via auditory stimulation on recovery after a concussion in children and adolescents in their home. Therefore, half of the patients receive one week of auditory stimulation during deep sleep at their home using a mobile device. The other half follows the same study protocol, but no tones are administered (sham). Cognitive tests as well as symptom questionnaires are used to assess the recovery process. It is hypothesized that the patients in the intervention group will recover better than the ones who haven't received the intervention. Additionally, a group of children and adolescents who never sustained a concussion is included as a control.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT04770116
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Auditory Stimulation
Trials testing the same drug.
- NCT07387107 — Decreasing Stress Via Virtual Reality and Binaural Beats in Non-Clinical Adults · NA · recruiting
- NCT07167316 — The Role of the LC-NA System in Experimental Sleep Fragmentation · Phase 1 · not yet recruiting
- NCT07116941 — Multisensory and Cognitive Interventions in the ICU: Effects on Health and Recovery · NA · recruiting
- NCT07402590 — Auditory Stimulation During Sleep to Enhance Long-Term Memory in Amnestic MCI · NA · completed
- NCT06905171 — Habituation of Brain Responses to Sensory Stimuli in Fibromyalgia · completed
Other University Children's Hospital, Zurich trials
Trials by the same sponsor.
- NCT07415577 — The Use of Cultured (Dermal) Epithelial Autografts in Severely Burned Patients · not yet recruiting
- NCT06852313 — Save the Ovaries - Surgical Management of Simple Ovarian Cysts in Children and Adolescents · NA · recruiting
- NCT07368166 — Development of the PTSD-iMPACT to Measure PTSD-Related Functional Impairment in Children and Adolescents - A Validation · recruiting
- NCT06950047 — PediLoc® Blade Plate in Distal Femoral Osteotomies · completed
- NCT05971264 — Comparison of Bladder Pressure Versus Regional Intestinal Tissue Oxygenation in Infants · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04770116 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Children's Hospital, Zurich
- Last refreshed: 9 December 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04770116.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing