Last reviewed · How we verify
NCT04765748: TAAA-Cytosorb
Cytokine Filter Usage During Open Thoracoabdominal Aortic Aneurysm Repair- a Single-center Randomized Prospective Trial
trial testing Cytosorb in Postoperative Complications in 20 participants. Completed in 27 December 2022.
27 November 2022
Quick facts
| Lead sponsor | RWTH Aachen University |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 20 |
| Start date | 11 February 2021 |
| Primary completion | 27 November 2022 |
| Estimated completion | 27 December 2022 |
| Sites | 1 location across Germany |
Drugs / interventions tested
- Cytosorb
Conditions studied
- Postoperative Complications — all drugs for Postoperative Complications →
- Inflammatory Response — all drugs for Inflammatory Response →
Sponsor
RWTH Aachen University
Who can join
Adults 18 to 85, any sex, with Postoperative Complications or Inflammatory Response. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Prospecrtive study including 20-30 randomized patients treated by open repair because of an TAAA larger than 55 mm During the surgery, a heart lung machine is applied for distal perfusion during aortic cross clamping to enable distal organ perfusion. Regardless an intensive inflammatory reaction is a well known effect after reperfusion, leading to a uncontrolled inflammation during th first days after surgery. This may be associated to bad outcome and decreased survival rates. By the application of a intraoperative cytokine and DAMP filter this negative ffect could be reduced, resulting in a better outcome after surgery.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Intraoperative Hemoadsorption (Cytosorb™) during Open Thoracoabdominal Aortic Repair: A Pilot Randomized Controlled Trial.
Doukas P, Hellfritsch G, Wendt D, Magliani M, et al · · 2023 · cited 15× · PMID 36675474 · DOI 10.3390/jcm12020546
Verify or expand the search:
- PubMed search for NCT04765748
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Trials testing the same drug.
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Other RWTH Aachen University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04765748 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by RWTH Aachen University
- Last refreshed: 10 April 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04765748.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing