Who is sponsoring NCT04765735?

NCT04765735 is sponsored by MedtronicNeuro.

What drugs are being tested in NCT04765735?

Interventions in NCT04765735: Open-loop testing, Closed-loop testing - External Spinal Cord Stimulator (SCS).

What condition does NCT04765735 study?

NCT04765735 studies Chronic Pain.

Is NCT04765735 still recruiting?

NCT04765735 is currently completed. Last updated 26 February 2024.

Are results published for NCT04765735?

Yes — primary outcome results have been posted to ClinicalTrials.gov. See the outcomes section above for details.

Last reviewed 2024-02-26 · How we verify

NCT04765735: ECHO-MAC

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Electrically Evoked Compound Action Potentials Human Observation Medtronic Algorithm Comparison Study

Completed NA Results posted Last updated 26 February 2024

What this trial tests

NA trial testing Open-loop testing, Closed-loop testing - External Spinal Cord Stimulator (SCS) in Chronic Pain in 52 participants. Completed in 29 June 2021.

Timeline

23 February 2021

Primary endpoint
29 June 2021

29 June 2021

Quick facts

Lead sponsor	MedtronicNeuro
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	single
Primary purpose	treatment
Enrollment	52
Start date	23 February 2021
Primary completion	29 June 2021
Estimated completion	29 June 2021
Sites	9 locations across United States

Drugs / interventions tested

Open-loop testing, Closed-loop testing - External Spinal Cord Stimulator (SCS)

Conditions studied

Chronic Pain — all drugs for Chronic Pain →

Sponsor

MedtronicNeuro — full company profile →

Who can join

22 and older, any sex, with Chronic Pain. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

The Proportion of Subjects With a Reduction in Overstimulation Sensation With SCS Using a Closed-loop Algorithm Compared With SCS in Open-loop Primary · In-clinic testing (1 day)

For every overstimulation sensation brought about by protocol-prescribed activities, subjects will rate the intensity of the sensation using a 5-point Likert scale. The average intensity score during OL and CL periods will be calculated for each subject. If the average intensity score during CL period is less than that from the OL period, the subject is considered as a subject with a reduction in overstimulation sensation during CL vs. OL period. The primary endpoint is the proportion of subjects with a reduction in overstimulation sensation among subjects who have in-clinic testing.

Group	Value	95% CI
Intent-to-treat (ITT)	41

Sponsor's own description

This is a prospective, multi-center, randomized, single-blind, cross-over, non-significant risk IDE research study to evaluate the in-clinic performance of a closed-loop algorithm in Spinal Cord Stimulation (SCS) therapy with an ENS device.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Closed-Loop Spinal Cord Stimulation in Chronic Pain Management: Mechanisms, Clinical Evidence, and Emerging Perspectives.
Mangano N, Torpey A, Devitt C, Wen GA, et al · · 2025 · cited 5× · PMID 40426918 · DOI 10.3390/biomedicines13051091

Verify or expand the search:

Other recruiting trials for Chronic Pain

Currently open trials in the same condition.

NCT07491549 — The Effect of Pain Education Group Therapy and Its Impact on Chronic Pain, Kinesiophobia, and Physical Activity · NA · recruiting
NCT07425691 — SPACE for Youth With Chronic Pain · recruiting
NCT07103135 — Optimizing Accelerated TMS for Chronic Pain With Thompson Sampling · Phase 1 · recruiting
NCT06219408 — CIH Stepped Care for Co-occurring Chronic Pain and PTSD · NA · recruiting
NCT07270406 — Healthy Behaviors for Insomnia Prevention in People With HIV and Ongoing Pain · NA · recruiting

Other MedtronicNeuro trials

Trials by the same sponsor.

NCT05775510 — Study to Evaluate Neuromodulation Subject Experience With Contemporary Spinal Cord Stimulation (SCS) Modalities for Chro · terminated
NCT05226286 — Evaluation of Implantable Tibial Neuromodulation Pivotal Study (TITAN 2) · NA · completed
NCT05200923 — Pelvic Health Electrically Evoked Recording (PEER) 2 Study · NA · recruiting
NCT05177354 — Medtronic Closed-Loop Spinal Cord Stimulation System · NA · completed
NCT07106242 — Adaptive Deep Brain Stimulation (aDBS) Study (Early Adapter) Part II · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04765735 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by MedtronicNeuro
Last refreshed: 26 February 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04765735.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing