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NCT04755400: APNI
The Effect of Orally Administrated Nitrate on Renal Parameters and Systemic Haemodynamics
NA trial testing isotonic saline 9% in Hypertension in 18 participants. Completed in 15 March 2020.
15 March 2020
Quick facts
| Lead sponsor | Frank Mose |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 18 |
| Start date | 1 September 2018 |
| Primary completion | 15 March 2020 |
| Estimated completion | 15 March 2020 |
| Sites | 1 location across Denmark |
Drugs / interventions tested
- isotonic saline 9%
- Potassium nitrate (POTASSIUM NITRATE) — full drug profile →
- Potassium chloride (POTASSIUM CHLORIDE) — full drug profile →
Conditions studied
- Hypertension — all drugs for Hypertension →
Sponsor
Frank Mose
Who can join
Adults 18 to 64, any sex, with Hypertension. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Treatment with nitrate has shown to lower blood pressure in both healthy subjects and hypertensive patients.Beside this nitrate have also shown to decrease arterial stiffness and improve endothelial function.But the effect of nitrate on renal blood flow, kidney function, water and salt balance and vasoactive hormones is still unclear. Therefore, the purpose of this study is to investigate the effect of orally administered nitrate on these parameters. This will be done in a double-blinded, placebo-controlled, crossover study. 20 healthy subjects will be treated, in a randomized order, with both potassium nitrate and placebo separated by at least 4 weeks wash-out.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT04755400
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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- NCT07238400 — Cardiac Effects of Mineralocorticoid Receptor Antagonism After Preeclampsia · Phase 2 · recruiting
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Other Frank Mose trials
Trials by the same sponsor.
- NCT06968182 — The Effect of Sodium on Erythrocyte Salt Sensitivity, Syndecan-1 and Heparin Sulfate in Healthy Subjects. · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04755400 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Frank Mose
- Last refreshed: 21 February 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04755400.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing