NCT04753021

Dose-response Relationship Between Exercise and Health Outcomes

Completed NA Last updated 12 April 2023

What this trial tests

NA trial testing Exercise in Mitochondrial Function in 11 participants. Completed in 23 March 2023.

Timeline

2 February 2018

Primary endpoint
11 November 2020

23 March 2023

Quick facts

Lead sponsor	The Swedish School of Sport and Health Sciences
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	basic science
Enrollment	11
Start date	2 February 2018
Primary completion	11 November 2020
Estimated completion	23 March 2023
Sites	1 location across Sweden

Drugs / interventions tested

• Exercise

Conditions studied

• Mitochondrial Function — all drugs for Mitochondrial Function →
• Glucose Intolerance — all drugs for Glucose Intolerance →

Sponsor

The Swedish School of Sport and Health Sciences

Who can join

Adults 18 to 50, any sex, with Mitochondrial Function or Glucose Intolerance. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

In this study 11 healthy volunteers will perform high intensity exercise training during 4 weeks. The exercise frequency will increase progressively during the first three weeks, followed by a fourth week with lower exercise frequency. 5 skeletal muscle biopsies will be donated throughout the study and 4 oral glucose tolerance tests will be performed after each training period.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. A Simple Model for Diagnosis of Maladaptations to Exercise Training.
   Flockhart M, Nilsson LC, Ekblom B, Larsen FJ. · · 2022 · cited 8× · PMID 36333619 · DOI 10.1186/s40798-022-00523-x