NCT04751864 is a Phase 4 clinical trial of Cranial Electrotherapy Stimulator (CES) Device in Anxiety, sponsored by ProofPilot.

Who is sponsoring NCT04751864?

NCT04751864 is sponsored by ProofPilot.

What drugs are being tested in NCT04751864?

Interventions in NCT04751864: Cranial Electrotherapy Stimulator (CES) Device.

What condition does NCT04751864 study?

NCT04751864 studies Anxiety, Generalized Anxiety Disorder, Generalized Anxiety.

Is NCT04751864 still recruiting?

NCT04751864 is currently active, enrolled. Last updated 12 February 2021.

Last reviewed 2021-02-12 · How we verify

NCT04751864

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Brain Stimulation & Generalized Anxiety Study

Active, enrolled Phase 4 Last updated 12 February 2021

What this trial tests

Phase 4 trial testing Cranial Electrotherapy Stimulator (CES) Device in Anxiety in 150 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

15 October 2020

Primary endpoint
31 March 2021

21 June 2021

Quick facts

Lead sponsor	ProofPilot
Phase	Phase 4
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	triple
Primary purpose	treatment
Enrollment	150
Start date	15 October 2020
Primary completion	31 March 2021
Estimated completion	21 June 2021
Sites	1 location across United States

Drugs / interventions tested

Cranial Electrotherapy Stimulator (CES) Device

Conditions studied

Anxiety — all drugs for Anxiety →
Generalized Anxiety Disorder — all drugs for Generalized Anxiety Disorder →
Generalized Anxiety — all drugs for Generalized Anxiety →

Sponsor

ProofPilot

Who can join

21 and older, any sex, with Anxiety or Generalized Anxiety Disorder. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Examine the safety and effectiveness of the Fisher Wallace Cranial Electrotherapy Stimulator (CES) Device on Generalized Anxiety Disorder using two (2) 20-minute per day treatment sessions over eight weeks.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Neuromodulation Strategies to Reduce Inflammation and Improve Lung Complications in COVID-19 Patients.
Czura CJ, Bikson M, Charvet L, Chen JDZ, et al · · 2022 · cited 13× · PMID 35911909 · DOI 10.3389/fneur.2022.897124
Trends of Decentralized Clinical Trials Using Digital Technology for Decentralization
Sato T, Mizumoto S, Ota M, Shikano M. · · 2022 · DOI 10.2139/ssrn.4243284

Verify or expand the search:

Other recruiting trials for Anxiety

Currently open trials in the same condition.

NCT07336238 — Group Retreat Psilocybin Therapy for the Treatment of Anxiety and Depression in Patients With Metastatic Solid Tumors or · Phase 2 · recruiting
NCT07522944 — AI-Guided Relaxation for Hemodialysis Anxiety · NA · recruiting
NCT07466875 — Auricular Stimulation for Nicotine Withdrawal in Psychiatric Inpatients · NA · recruiting
NCT07425951 — Building Cognitive Behavioural Skills With StoryBooks to Reduce Emotional Difficulties in Kindergarten Years · NA · recruiting
NCT07473505 — Integrative Bilateral Cervical Sympathetic Blocks for Trauma-Related Symptoms in Special Operations Veterans: A Prospect · recruiting

Other ProofPilot trials

Trials by the same sponsor.

NCT04914533 — Luminance RED for Canker Sores · NA · withdrawn
NCT04627480 — Evaluation of a Neurostimulation Device for Insomnia: A Randomized Trial · Phase 4 · active not recruiting
NCT04541563 — Fisher Wallace Neurostimulation & Depression Study · NA · active not recruiting
NCT04471896 — Joovvin' for Your Skin Health Study · NA · completed
NCT04245254 — GutMe!: IBS and Collagen Protein Powder an Interventional Study · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04751864 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by ProofPilot
Last refreshed: 12 February 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04751864.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing