NCT04749992: BFD

Biological Function of Dreaming in Dreaming and Non-Dreaming Patients With PCA Infarction

Terminated Last updated 12 March 2024

What this trial tests

trial testing Polysomnographic examination in sleep laboratory (PSG measurement) in Dream Disorder in 142 participants. Terminated before completion.

Timeline

1 August 2018

Primary endpoint
8 March 2024

8 March 2024

Quick facts

Lead sponsor	International Psychoanalytic University Berlin
Status	Terminated
Study type	OBSERVATIONAL
Enrollment	142
Start date	1 August 2018
Primary completion	8 March 2024
Estimated completion	8 March 2024
Sites	2 locations across Germany

Drugs / interventions tested

• Polysomnographic examination in sleep laboratory (PSG measurement)

Conditions studied

• Dream Disorder — all drugs for Dream Disorder →
• Thrombotic Infarction — all drugs for Thrombotic Infarction →
• PCA Infarct — all drugs for PCA Infarct →

Sponsor

International Psychoanalytic University Berlin

Who can join

Adults 18 to 90, any sex, with Dream Disorder or Thrombotic Infarction. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study is a quasi-experimental between-group design. Using a prospective two-arm controlled exploratory study, data will be collected on an initial assessment of the effects of a specific neurological sample after thrombotic infarction (PCA infarction) who lost the ability to dream due to the infarction (experimental group) compared to a specific neurological sample after thrombotic infarction (PCA infarction) without loss of the ability to dream (comparison group) in terms of subjective and objective sleep quality and memory consolidation. Besides the importance to further elucidate the role of dreaming for sleep architecture and memory consolidation, the results of the evaluation are of great clinical relevance in a further scientific investigation regarding the treatment of a specifically neurological sample with acute thrombotic infarction.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Converging theories on dreaming: Between Freud, predictive processing, and psychedelic research.
   Koslowski M, de Haas MP, Fischmann T. · · 2023 · cited 8× · PMID 36875230 · DOI 10.3389/fnhum.2023.1080177
2. Exploring the biological function of dreaming: lessons learned from recruitment challenges in a pilot study with PCA stroke patients.
   Fischmann T, Peters L, Rieker V, Koslowski M. · · 2025 · PMID 41425211 · DOI 10.3389/frsle.2025.1585263