Last reviewed · How we verify
NCT04747626: B-SAFER
B-SAFER: Branched Stented Anastomosis Frozen Elephant Trunk Repair
NA trial testing B-SAFER in Thoracic Aortic Aneurysm in 590 participants. Currently enrolling.
31 December 2030
Quick facts
| Lead sponsor | Eric Roselli, M. D. |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 590 |
| Start date | 25 March 2021 |
| Primary completion | 31 December 2030 |
| Estimated completion | 31 December 2030 |
| Sites | 1 location across United States |
Drugs / interventions tested
- B-SAFER
Conditions studied
- Thoracic Aortic Aneurysm — all drugs for Thoracic Aortic Aneurysm →
- Aortic Dissection — all drugs for Aortic Dissection →
- Congenital Aortic Anomaly — all drugs for Congenital Aortic Anomaly →
Sponsor
Eric Roselli, M. D.
Who can join
18 and older, any sex, with Thoracic Aortic Aneurysm or Aortic Dissection. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
A prospective, single-center, non-blind, non-randomized safety and feasibility study of the hybrid repair of thoracic aortic pathologies requiring repair of the aortic arch proximal to the origin of innominate artery.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Hybrid repair versus conventional open repair for thoracic aortic arch aneurysms.
Elhelali A, Hynes N, Devane D, Sultan S, et al · · 2021 · cited 13× · PMID 34085713 · DOI 10.1002/14651858.cd012923.pub2 -
Anomalous left vertebral artery in patients undergoing total arch replacement: Results from a prospective trial.
Bhagat R, Snyder A, Vargo P, Hussain MS, et al · · 2026 · PMID 41971881 · DOI 10.1016/j.xjtc.2026.102270 -
Aortic Dissection Registries: The Tools to Keep Us in Check.
Koprivanac M, Roselli EE, Bakaeen FG. · · 2022 · PMID 36713765 · DOI 10.1016/j.jacasi.2022.09.009
Verify or expand the search:
- PubMed search for NCT04747626
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Thoracic Aortic Aneurysm
Currently open trials in the same condition.
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- NCT06353607 — Genetic Architecture of Acute Aortic Syndromes and Aortic Aneurysm. · recruiting
- NCT06336213 — Antibacterial Tactics Based on Presepsin Level in Thoracic Aorta Surgery Patients · NA · recruiting
- NCT06094127 — Zenith Thoracic Alpha (ZTA) Post-Market Data Collection · active not recruiting
- NCT06882967 — Active Thoracic Compromised Distal LANding in TEvar · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04747626 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Eric Roselli, M. D.
- Last refreshed: 9 October 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04747626.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing