NCT04747587: OPTISTROKE

Non-use After Stroke: Influence of Applied Force and Precision When Reaching With the Paretic Upper Limb

Completed NA Last updated 18 December 2025

What this trial tests

NA trial testing Reaching Session in Stroke in 53 participants. Completed in 25 April 2023.

Timeline

11 May 2021

Primary endpoint
25 April 2023

25 April 2023

Quick facts

Lead sponsor	Centre Hospitalier Universitaire de Nīmes
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	none
Primary purpose	other
Enrollment	53
Start date	11 May 2021
Primary completion	25 April 2023
Estimated completion	25 April 2023
Sites	2 locations across France

Drugs / interventions tested

• Reaching Session

Conditions studied

• Stroke — all drugs for Stroke →

Sponsor

Centre Hospitalier Universitaire de Nīmes

Who can join

18 and older, any sex, with Stroke. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

After a stroke, 80% of patients have an upper limb deficit, limiting activity. Some develop a non-use: they can, but do not, use their paretic limb. Non-use is a general phenomenon applied to all situations where the patient applies unnecessary compensation. Several rehabilitation techniques are effective to counter non-use, but there is insufficient knowledge to choose the most suitable technique. Optimal control theory could help guide these choices. It assumes that the chosen coordination satisfies the constraints of the task (force, amplitude, tolerance) while reducing the cost of the movement. This study will assess non-use by anticipating the sensitivity to the constraints of force and precision deduced from the logic of optimal control. The study authors expect to observe a weakness effect: in a reaching task (i.e. when the person has to touch an object placed in front of them), lightening the paretic arm makes it possible to reduce non-use, and a precision effect: in a reaching task, non-use increases with the required spatial precision.

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

1. Validity and Reliability of Kinect v2 for Quantifying Upper Body Kinematics during Seated Reaching.
   Faity G, Mottet D, Froger J. · · 2022 · cited 23× · PMID 35408349 · DOI 10.3390/s22072735
2. Force reserve predicts compensation in reaching movement with induced shoulder strength deficit.
   Faity G, Barradas VR, Schweighofer N, Mottet D. · · 2024 · cited 2× · PMID 38985941 · DOI 10.1152/jn.00143.2024
3. Neuromechanics of Nonuse and Compensation: Implications for Rehabilitation After Stroke.
   Faity G, Mottet D, Froger J, Delorme M. · · 2026 · PMID 42080459 · DOI 10.1177/15459683261445442
4. Neuromechanics of nonuse and compensation: implications for rehabilitation after stroke
   Faity G, Mottet D, Froger J, Delorme M. · · 2025 · DOI 10.1101/2025.09.11.25335554
5. Target height influences shoulder and elbow non-use after stroke during reaching with the hand : A brief communication
   Faity G, Mottet D, Froger J. · · 2022 · DOI 10.1101/2022.12.20.22283739