NCT04746677

Safety and Efficacy of Endovascular Repair of Complex Aortic Pathology With Physician-modified Endovascular Grafts (PMEGs)

Recruiting now NA Last updated 8 April 2026

What this trial tests

NA trial testing Endovascular aortic repair with a physician-modified endovascular graft (PMEG) in Abdominal Aortic Aneurysm in 220 participants. Currently enrolling.

Timeline

15 March 2021

Primary endpoint
31 March 2031

31 March 2031

Quick facts

Lead sponsor	Beth Israel Deaconess Medical Center
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	220
Start date	15 March 2021
Primary completion	31 March 2031
Estimated completion	31 March 2031
Sites	1 location across United States

Drugs / interventions tested

• Endovascular aortic repair with a physician-modified endovascular graft (PMEG)
• TREO graft

Conditions studied

• Abdominal Aortic Aneurysm — all drugs for Abdominal Aortic Aneurysm →
• Thoracoabdominal Aortic Aneurysm — all drugs for Thoracoabdominal Aortic Aneurysm →
• Aortic Dissection — all drugs for Aortic Dissection →

Sponsor

Beth Israel Deaconess Medical Center

Who can join

21 and older, any sex, with Abdominal Aortic Aneurysm or Thoracoabdominal Aortic Aneurysm. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The primary objective of this study is to examine the safety and effectiveness of physician-modified endovascular grafts (PMEGs) for endovascular repair of complex aortic pathology in high-risk patients. The study is divided into three study arms based on the subject's aortic pathology: (1) Complex abdominal aortic aneurysm (AAA); (2) Thoracoabdominal aortic aneurysm; and (3) Aortic dissection.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. A computational program for automated surgical planning of fenestrated endovascular repair
   Dillon T, Liang P, Schermerhorn M, Roche E. · · 2023