Who is sponsoring NCT04744883?

NCT04744883 is sponsored by Rush University Medical Center.

What drugs are being tested in NCT04744883?

Interventions in NCT04744883: Spinal Manipulation Therapy (SMT), Naloxone, Placebo, Mindfulness Based Stress Reduction Therapy (MT).

What condition does NCT04744883 study?

NCT04744883 studies Chronic Low-back Pain.

Is NCT04744883 still recruiting?

NCT04744883 is currently active, enrolled. Last updated 10 July 2025.

Last reviewed 2025-07-10 · How we verify

NCT04744883

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Efficacy of Spinal Manipulation Therapy or Mindfulness-based Reduction Therapy on Patients With Chronic Low Back Pain

Active, enrolled EARLY_PHASE1 Last updated 10 July 2025

What this trial tests

EARLY_PHASE1 trial testing Spinal Manipulation Therapy (SMT) in Chronic Low-back Pain in 140 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

15 August 2020

Primary endpoint
29 November 2024

1 June 2026

Quick facts

Lead sponsor	Rush University Medical Center
Phase	EARLY_PHASE1
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	140
Start date	15 August 2020
Primary completion	29 November 2024
Estimated completion	1 June 2026
Sites	2 locations across United States

Drugs / interventions tested

Spinal Manipulation Therapy (SMT)
Naloxone (NALOXONE) — full drug profile →
Placebo
Mindfulness Based Stress Reduction Therapy (MT)

Conditions studied

Chronic Low-back Pain — all drugs for Chronic Low-back Pain →

Sponsor

Rush University Medical Center

Who can join

Adults 18 to 75, any sex, with Chronic Low-back Pain. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Chronic Pain Management (CPM) has increasingly utilized long-term opioid analgesic therapy, a change associated with increased opioid abuse (a greater exposure in vulnerable individuals), non-pain health consequences (hormone changes, falls), and a dramatic rise in opioid-related overdoses and deaths. Treatment strategies that minimize the need for chronic high-dose opioids are sorely needed. This project will aim to test what degree mindfulness therapy (MT) and spinal manipulation therapy (SMT) produce pre- to mid- to post-treatment changes in endogenous opioid (EO) function.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other trials of Spinal Manipulation Therapy (SMT)

Trials testing the same drug.

NCT04142177 — Sequential and Comparative Evaluation of Pain Treatment Effectiveness Response · NA · recruiting
NCT03581123 — Spinal Manipulation and Patient Self-Management for Preventing Acute to Chronic Back Pain · Phase 3 · completed

Other recruiting trials for Chronic Low-back Pain

Currently open trials in the same condition.

NCT06891625 — Movement Performance in Persons With Chronic Back Pain · NA · recruiting
NCT06568198 — Modulation Effect of tACS on Chronic Low Back Pain · Phase 2 · recruiting
NCT06825390 — AuriculoTherapy NeuroImaging · NA · recruiting
NCT04824248 — Weight Reduction in CLBP · NA · recruiting
NCT07055802 — Effects Of Inversion Table Therapy Vs MT On Pain And Lumbar Flexibility In Patients With Chronic Low Back Pain · NA · active not recruiting

Other Rush University Medical Center trials

Trials by the same sponsor.

NCT07278076 — Clinical Decision-Making During FEES: The Impact of Residue Amount and Location · NA · not yet recruiting
NCT07088120 — PRECISION-CPR: PRecision-Controlled Ventilation in CPR · NA · not yet recruiting
NCT06894719 — Oral Tranexamic Acid After Total Knee Arthroplasty · Phase 4 · not yet recruiting
NCT06229392 — A Study to Evaluate the Intratumoral Influenza Vaccine Administration in Patients With Breast Cancer · Phase 1 · withdrawn
NCT07452406 — Protocolized Weaning of High-Flow Nasal Cannula in Adult Patients · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04744883 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Rush University Medical Center
Last refreshed: 10 July 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04744883.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing