Last reviewed · How we verify
NCT04743245
Delivery SSO2 Therapy for 60 Min in Anterior MI Patients With PCI ≤ 6 Hours of Symptoms Onset Compared to Standard.
NA trial testing TherOx DownStream System in Acute Myocardial Infarction in 434 participants. Currently enrolling.
31 July 2026
Quick facts
| Lead sponsor | TherOx |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 434 |
| Start date | 2 August 2022 |
| Primary completion | 31 July 2026 |
| Estimated completion | 31 July 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- TherOx DownStream System
- PCI
Conditions studied
- Acute Myocardial Infarction — all drugs for Acute Myocardial Infarction →
- STEMI — all drugs for STEMI →
Sponsor
TherOx — full company profile →
Who can join
18 and older, any sex, with Acute Myocardial Infarction or STEMI. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
A multi-center randomized post-approval evaluation of delivery of intracoronary hyperoxemic supersaturated Oxygen therapy for 60 minutes in anterior AMI patients with successful reperfusion (via PCI) within 6 hours after onset of symptoms compared to standard therapy
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Treatment and Care of Patients with ST-Segment Elevation Myocardial Infarction-What Challenges Remain after Three Decades of Primary Percutaneous Coronary Intervention?
Zuccarelli V, Andreaggi S, Walsh JL, Kotronias RA, et al · · 2024 · cited 7× · PMID 38792463 · DOI 10.3390/jcm13102923 -
State of the Art of Primary PCI: Present and Future.
Mignatti A, Echarte-Morales J, Sturla M, Latib A. · · 2025 · cited 5× · PMID 39860658 · DOI 10.3390/jcm14020653 -
Therapeutic hypothermia to reduce infarct size in STEMI: time to give it the cold shoulder?
Hausenloy DJ, Bulluck H. · · 2024 · PMID 39229887 · DOI 10.4244/eij-e-24-00032
Verify or expand the search:
- PubMed search for NCT04743245
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Acute Myocardial Infarction
Currently open trials in the same condition.
- NCT03951467 — Using an Intervention Adapted to the Health Literacy Level to Improve Adherence to Medical Recommendations · NA · recruiting
- NCT07536802 — Adenosine Pre-Medication in Primary Percutaneous Coronary Intervention: A Randomized Control Trial · Phase 4 · recruiting
- NCT06947135 — Stellate Ganglion Morphine Infiltration on Myocardial Ischemia-Reperfusion Injury · NA · recruiting
- NCT06515730 — Treatment With Apixaban Versus Warfarin in Patients With Left Ventricular Thrombus After Acute Myocardial Infarction · Phase 4 · recruiting
- NCT07522164 — Acute Myocardial Infarction Clinical Cohort · active not recruiting
Other TherOx trials
Trials by the same sponsor.
- NCT05156996 — A Prospective Real-World Multi-Center Post-Market Observational Evaluation of Supersaturated O2 Therapy Using the TherOx · terminated
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04743245 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by TherOx
- Last refreshed: 14 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04743245.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing