NCT04736693 is a clinical trial of Raloxifene in Osteoporosis, sponsored by Brigham and Women's Hospital.

Who is sponsoring NCT04736693?

NCT04736693 is sponsored by Brigham and Women's Hospital.

What drugs are being tested in NCT04736693?

Interventions in NCT04736693: Raloxifene, Zoledronic Acid.

What condition does NCT04736693 study?

NCT04736693 studies Osteoporosis.

Is NCT04736693 still recruiting?

NCT04736693 is currently completed. Last updated 27 July 2023.

Last reviewed 2023-07-27 · How we verify

NCT04736693

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Replication of the HORIZON Pivotal Fracture Trial in Healthcare Claims Data

Completed Last updated 27 July 2023

What this trial tests

trial testing Raloxifene in Osteoporosis in 18,028 participants. Completed in 18 February 2021.

Timeline

22 September 2020

Primary endpoint
18 February 2021

18 February 2021

Quick facts

Lead sponsor	Brigham and Women's Hospital
Status	Completed
Study type	OBSERVATIONAL
Enrollment	18,028
Start date	22 September 2020
Primary completion	18 February 2021
Estimated completion	18 February 2021
Sites	1 location across United States

Drugs / interventions tested

Raloxifene (RALOXIFENE) — full drug profile →
Zoledronic Acid (ZOLEDRONIC ACID) — full drug profile →

Conditions studied

Osteoporosis — all drugs for Osteoporosis →

Sponsor

Brigham and Women's Hospital

Who can join

65 and older, female only, with Osteoporosis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Investigators are building an empirical evidence base for real world data through large-scale replication of randomized controlled trials. The investigators' goal is to understand for what types of clinical questions real world data analyses can be conducted with confidence and how to implement such studies.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Efficacy Versus Effectiveness: The HORIZON-Pivotal Fracture Trial and Its Emulation in Claims Data.
D'Andrea E, Schneeweiss S, Franklin JM, Kim SC, et al · · 2025 · cited 4× · PMID 39129266 · DOI 10.1002/art.42968

Verify or expand the search:

Other trials of Raloxifene

Trials testing the same drug.

NCT06055179 — XCHT for Irinotecan-Induced Gut Toxicities (Randomized Controlled Trial) · NA · recruiting
NCT04926545 — XCHT for Irinotecan-Induced Gut Toxicities (Run-in Study) · NA · completed
NCT05172050 — Multicenter Double Blind, Parallel-group Phase 2/3 Trial, to Study Raloxifene in Adult COVID-19 Patients. · Phase 2, PHASE3 · completed
NCT03010267 — DP-R213 Phase 1 Pharmacokinetics Study · Phase 1 · completed
NCT01416194 — Bazedoxifene Post Approval Safety Study (PASS) in the European Union (EU) · completed

Other recruiting trials for Osteoporosis

Currently open trials in the same condition.

NCT07027306 — The Osteoporotic Fracture Classification-based Scoring System for Treatment Decision in Thoracolumbar Osteoporotic Fract · recruiting
NCT07367776 — Patient Education in Osteoporosis (RCT-PATOS) · NA · recruiting
NCT06731608 — OsteoPorotic fracTure preventION System (OPTIONS) Research Study · NA · recruiting
NCT07281586 — Step-down Therapy After Long-term Osteoporosis Treatment · Phase 4 · recruiting
NCT07083557 — Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiome · recruiting

Other Brigham and Women's Hospital trials

Trials by the same sponsor.

NCT07011758 — Dynamic Treatment Regimes for Opioid Use Disorder · Phase 2 · not yet recruiting
NCT06310018 — Augmented Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for PE · suspended
NCT04519177 — Randomized Trial of a Sleep Disorders Program on Firefighter Safety and Disability ... · NA · not yet recruiting
NCT06355986 — Computerized Decision Support to Prevent Stroke in Atrial Fibrillation · NA · not yet recruiting
NCT06099275 — Evaluation of Hemodynamics in People With Untreated Preeclampsia Using Echocardiography · suspended

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04736693 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Brigham and Women's Hospital
Last refreshed: 27 July 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04736693.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing