NCT04731870

Exploring Vaccine Confidence and Uptake of Potential COVID-19 Vaccines

Completed Last updated 27 July 2023

What this trial tests

trial testing Survey research in Coronavirus in 632 participants. Completed in 31 March 2023.

Timeline

28 February 2021

Primary endpoint
1 January 2023

31 March 2023

Quick facts

Lead sponsor	East Carolina University
Status	Completed
Study type	OBSERVATIONAL
Enrollment	632
Start date	28 February 2021
Primary completion	1 January 2023
Estimated completion	31 March 2023
Sites	1 location across United States

Drugs / interventions tested

• Survey research

Conditions studied

• Coronavirus — all drugs for Coronavirus →

Sponsor

East Carolina University

Who can join

Adults 18 to 100, any sex, with Coronavirus. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The COVID-19 pandemic has highlighted deleterious US health inequities. Specifically, African Americans, Latinos, and Native Americans have and continue to shoulder a greater burden of COVID-19 infections and deaths in the US. In addition to existing racial and ethnic disparities are rural health and regional disparities. Given the disproportionate impact of disease in US communities of color and also in rural and southern regions of the US, there is no doubt that these at-risk subgroups will continue to experience higher rates of coronavirus-related mortality as well as other long-term health outcomes as compared to other US populations.

It is unknown how healthcare providers and other key at-risk subgroups within the US will receive COVID-19 vaccines. For success in immunizations, the US will need to reach their most at-risk and vulnerable populations. In addition to at-risk populations, a successful immunization strategy will involve engaging providers to support clear, consistent, and strong vaccine recommendation. It is critical to build vaccine trust, confidence, and overall acceptance of COVID-19 vaccines among healthcare providers and key at-risk subgroups, especially given the accelerated production timeline of these vaccines. Likewise, tailored vaccine messaging for key subgroups is vital in achieving vaccine confidence and trust.

The proposed study will explore perceptions, confidence, trust, and uptake of potential COVID-19 vaccines among healthcare providers (nurses and doctors) and key at-risk population subgroups (minority populations living in the rural south) and will develop and test vaccine messaging that boosts vaccine confidence and trust among these key at-risk subgroups.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Interventions to increase COVID-19 vaccine uptake: a scoping review.
   Andreas M, Iannizzi C, Bohndorf E, Monsef I, et al · · 2022 · cited 24× · PMID 35920693 · DOI 10.1002/14651858.cd015270