NCT04731779 is a EARLY_PHASE1 clinical trial of cannabidiol in Healthy, sponsored by Castleton University.

Who is sponsoring NCT04731779?

NCT04731779 is sponsored by Castleton University.

What drugs are being tested in NCT04731779?

Interventions in NCT04731779: cannabidiol, Placebo.

Is NCT04731779 still recruiting?

NCT04731779 is currently completed. Last updated 15 May 2023.

Last reviewed 2023-05-15 · How we verify

NCT04731779

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Cannabidiol and Autonomic Function at Rest

Completed EARLY_PHASE1 Last updated 15 May 2023

What this trial tests

EARLY_PHASE1 trial testing cannabidiol in Healthy in 18 participants. Completed in 29 November 2021.

Timeline

30 August 2021

Primary endpoint
29 November 2021

29 November 2021

Quick facts

Lead sponsor	Castleton University
Phase	EARLY_PHASE1
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	triple
Primary purpose	basic science
Enrollment	18
Start date	30 August 2021
Primary completion	29 November 2021
Estimated completion	29 November 2021
Sites	1 location across United States

Drugs / interventions tested

cannabidiol (CANNABIDIOL) — full drug profile →
Placebo

Conditions studied

Healthy — all drugs for Healthy →

Sponsor

Castleton University

Who can join

Adults 18 to 35, any sex, with Healthy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Cannabidiol (CBD) is one of 700 chemicals derived from the Cannabis sativa plant and is both legal and widespread for distribution in the state of Vermont. The central hypothesis of this proposal is that in apparently healthy adults, acute CBD favorably affects the autonomic nervous system and that this will be evident by an increase in heart rate variability. The overall goal is to understand how CBD affects the autonomic and cardiovascular systems at rest, and when perturbed. The investigators will study a narrow age range of adults, administer varying acute doses of CBD, characterize baseline cardiovascular variables, and record responses to autonomic challenge maneuvers. This will provide the framework to assess potential therapies and/or risk factors of CBD, particularly as it relates to healthy individuals. More information that is so widely taken, especially one that targets receptors known to be involved in cardiovascular signaling pathways is imperative.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

Other trials of cannabidiol

Trials testing the same drug.

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NCT05646459 — Effect of Local Cannabidiol on Clinical and Inflammatory Outcomes in Periodontal Maintenance Patients. · Phase 1 · withdrawn
NCT04271917 — Analgesic Effects of Cannabidiol for Simple Tooth Extractions in Dental Patients · Phase 3 · completed
NCT03196466 — Population Pharmacokinetics of Antiepileptic in Pediatrics · completed
NCT02461706 — Treatment of Drug Resistant Epilepsy · no longer available

Other recruiting trials for Healthy

Currently open trials in the same condition.

NCT06707207 — Predicting Future Errors During Skill Performance · recruiting
NCT07169630 — PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI) · Phase 1 · recruiting
NCT07499414 — The Effects of the Bile Acid Supplement, 7-keto Lithocholic Acid, on Human Gut Microbiota and Risk Factors for Disease. · NA · recruiting
NCT07496697 — Effects of Electroacupuncture at NP82 and SP15 on Bowel Motility in Healthy Subjects · NA · recruiting
NCT06431932 — Pilot Trial of Fisetin in Healthy Volunteers and Older Patients With Multimorbidity · Phase 1, PHASE2 · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04731779 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Castleton University
Last refreshed: 15 May 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04731779.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing