Last reviewed · How we verify
NCT04730310
Anesthesia Technique and Lower Limb Revascularization Patency
trial testing NSQIP Lower Extremity Open (LEO) procedure-targeted dataset (i.e. undergoing Lower extremity open revascularization) from 2014-2019 in Regional Anesthesia, Vascular Grafting, Vascular Patency in 8,893 participants. Completed in 31 March 2022.
28 February 2022
Quick facts
| Lead sponsor | University of British Columbia |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 8,893 |
| Start date | 1 February 2021 |
| Primary completion | 28 February 2022 |
| Estimated completion | 31 March 2022 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- NSQIP Lower Extremity Open (LEO) procedure-targeted dataset (i.e. undergoing Lower extremity open revascularization) from 2014-2019
Conditions studied
- Regional Anesthesia, Vascular Grafting, Vascular Patency — all drugs for Regional Anesthesia, Vascular Grafting, Vascular Patency →
Sponsor
University of British Columbia
Who can join
Adults 18 to 110, any sex, with Regional Anesthesia, Vascular Grafting, Vascular Patency. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The role of regional anesthesia in lower extremity revascularization procedures on reducing graft failure and need for reoperation remains unclear. In this study, we will analyze data from the multicenter National Surgical Quality Improvement Program (ACS NSQIP®) to assess the association between regional anesthesia (RA) and graft outcomes, as compared to general anesthesia (GA). Our primary objective is to determine for patients undergoing elective open lower limb revascularization, whether RA (spinal, epidural, and peripheral nerve block), compared to GA or general anesthesia with regional anesthesia (GA+RA), is associated with higher rates of patent graft within 30 days postoperatively (primary outcome).
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Association of anaesthesia technique with 30-day primary graft patency after open lower limb revascularization: retrospective cohort study.
Ke JXC, Flexman AM, Schwarz SKW, MacDonald S, et al · · 2022 · cited 4× · PMID 35657135 · DOI 10.1093/bjsopen/zrac061
Verify or expand the search:
- PubMed search for NCT04730310
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04730310 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of British Columbia
- Last refreshed: 11 January 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04730310.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing