NCT04729855

Association of Autophagy-related Genes ,LncRNA and SNPs With Colorectal Cancer in Egyptian Population

Completed Last updated 30 April 2025

What this trial tests

trial testing PBMCs and Tissue expression of HOTTIP ,EIF4EBP1 and serum SNP HOTTIP rs1859168 in Colo-rectal Cancer in 60 participants. Completed in 20 September 2024.

Timeline

15 April 2022

Primary endpoint
20 May 2023

20 September 2024

Quick facts

Lead sponsor	Esraa Hassan,MD
Status	Completed
Study type	OBSERVATIONAL
Enrollment	60
Start date	15 April 2022
Primary completion	20 May 2023
Estimated completion	20 September 2024
Sites	1 location across Egypt

Drugs / interventions tested

• PBMCs and Tissue expression of HOTTIP ,EIF4EBP1 and serum SNP HOTTIP rs1859168

Conditions studied

• Colo-rectal Cancer — all drugs for Colo-rectal Cancer →

Sponsor

Esraa Hassan,MD

Who can join

Adults 25 to 65, any sex, with Colo-rectal Cancer. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

1. Determination of expression level of HOTTIP and EIF4EBP1(Eukaryotic translation initiation factor 4E-binding protein 1) .
2. Investigation of the SNP HOTTIP rs1859168 and it's association with CRC susceptibility.
3. Correlation of the expression of these genes with various stages of CRC to determine the prognostic value of each of them.

Publications & conference data

7 peer-reviewed publications reference this trial (live from Europe PMC):

1. Long Non-Coding RNAs in Colorectal Cancer: Navigating the Intersections of Immunity, Intercellular Communication, and Therapeutic Potential.
   Shakhpazyan NK, Mikhaleva LM, Bedzhanyan AL, Sadykhov NK, et al · · 2023 · cited 20× · PMID 37760852 · DOI 10.3390/biomedicines11092411
2. Discovery and Validation of Clinically Relevant Long Non-Coding RNAs in Colorectal Cancer.
   Snyder M, Iraola-Guzmán S, Saus E, Gabaldón T. · · 2022 · cited 14× · PMID 36010859 · DOI 10.3390/cancers14163866
3. Long non-coding RNAs in ferroptosis, pyroptosis and necroptosis: from functions to clinical implications in cancer therapy.
   Huang K, Yu L, Lu D, Zhu Z, et al · · 2024 · cited 10× · PMID 39267831 · DOI 10.3389/fonc.2024.1437698
4. The Interplay between Autophagy and Mitochondria in Cancer.
   Zdanowicz A, Grosicka-Maciąg E. · · 2024 · cited 9× · PMID 39273093 · DOI 10.3390/ijms25179143
5. Systematic Investigation of the Diagnostic and Prognostic Impact of LINC01087 in Human Cancers.
   De Palma FDE, Carbonnier V, Salvatore F, Kroemer G, et al · · 2022 · cited 7× · PMID 36497462 · DOI 10.3390/cancers14235980
6. Targeting Regulatory Noncoding RNAs in Human Cancer: The State of the Art in Clinical Trials.
   Piergentili R, Sechi S. · · 2025 · cited 2× · PMID 40284466 · DOI 10.3390/pharmaceutics17040471
7. Landscape of Noncoding RNA in the Hypoxic Tumor Microenvironment.
   Gong L, Zou C, Zhang H, Yang F, et al · · 2025 · PMID 40004471 · DOI 10.3390/genes16020140