Who is sponsoring NCT04729478?

NCT04729478 is sponsored by ethisch.comite@uza.be.

What drugs are being tested in NCT04729478?

Interventions in NCT04729478: Drug-induced sleep endoscopy, Natural sleep endoscopy.

What condition does NCT04729478 study?

NCT04729478 studies Sleep Apnea, Obstructive, Sleep Apnea, Sleep Apnea Syndromes, Apnea, Respiration Disorder, Respiratory Tract Disease, Dyssomnia, Sleep Disorders, Intrinsic, Sleep Wake Disorders, Nervous System Diseases, Hypnotics and Sedatives, Central Nervous System Depressants, Propofol, Midazolam, Physiological Effects of Drugs, General Anesthetics.

Is NCT04729478 still recruiting?

NCT04729478 is currently status unknown. Last updated 26 July 2021.

Last reviewed 2021-07-26 · How we verify

NCT04729478

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Comparison Between Natural Sleep Endoscopy and Drug-induced Sleep Endoscopy in Patients With Obstructive Sleep Apnea

Status unknown NA Last updated 26 July 2021

What this trial tests

NA trial testing Drug-induced sleep endoscopy in Sleep Apnea, Obstructive in 40 participants. Status unknown.

Timeline

30 March 2021

Primary endpoint
31 August 2022

31 December 2022

Quick facts

Lead sponsor	ethisch.comite@uza.be
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	non randomized
Design	single group
Masking	single
Primary purpose	diagnostic
Enrollment	40
Start date	30 March 2021
Primary completion	31 August 2022
Estimated completion	31 December 2022
Sites	1 location across Belgium

Drugs / interventions tested

Drug-induced sleep endoscopy
Natural sleep endoscopy

Conditions studied

Sleep Apnea, Obstructive — all drugs for Sleep Apnea, Obstructive →
Sleep Apnea — all drugs for Sleep Apnea →
Sleep Apnea Syndromes — all drugs for Sleep Apnea Syndromes →
Apnea — all drugs for Apnea →

Sponsor

ethisch.comite@uza.be

Who can join

18 and older, any sex, with Sleep Apnea, Obstructive or Sleep Apnea. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Drug-induced sleep endoscopy (DISE) is the most used technique for identifying the obstruction site associated with obstructive sleep apnea (OSA). This is due to the fact that it allows many patients to be examined in a daytime setting. This procedure uses sedative drugs to mimic natural sleep. However, associations with the site of upper airway (UA) collapse during natural sleep remain unclear. The aim of this explorative study is to identify UA collapse in patients with OSA using endoscopic techniques as well as flow shape characteristics and sound analyses during natural and drug-induced sleep. Furthermore, we want to optimize the measurement set-up of natural sleep endoscopy (NSE).

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Comparison of Drug-Induced Sleep Endoscopy and Natural Sleep Endoscopy in the Assessment of Upper Airway Pathophysiology During Sleep: Protocol and Study Design.
Van den Bossche K, Van de Perck E, Wellman A, Kazemeini E, et al · · 2021 · cited 6× · PMID 34950101 · DOI 10.3389/fneur.2021.768973

Verify or expand the search:

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Other ethisch.comite@uza.be trials

Trials by the same sponsor.

NCT04170959 — The Addition of Metformin to Definitive Radiotherapy in Patients With Stage III NSCLC · Phase 2 · terminated

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04729478 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by ethisch.comite@uza.be
Last refreshed: 26 July 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04729478.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing